DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chm and KAT8

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_892003.2	Gene:	KAT8 / 84148	HGNCID:	17933	Length:	467	Species:	Homo sapiens

Alignment Length:	365	Identity:	160/365 - (43%)
Similarity:	223/365 - (61%)	Gaps:	39/365 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 PEQREFLAKIRESRANFKPANNNF----------LDSKV--------KLEKDVTDEDREPNLAGL 495
            |:.....|::.:||.|.:.....|          ||..|        |..||...::.|..|:.|
Human    66 PDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSEL 130

  Fly   496 VPDYDLQLFREAQAQASE----------------RIEDELKDLPVGKGIKYISMGKYKMKVWYQS 544
            ....:.::.|..:.:..|                .:|.|.:.:...|.:..|.:|.|::..||.|
Human   131 AEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFS 195

  Fly   545 PYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYC 609
            |:|:|..:.||:::||:||:|.|.|...:.|..:|.||.|||.|||||..:.|::||||.:|.||
Human   196 PFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYC 260

  Fly   610 QHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLP 674
            |:||||||.||||||||:|||||:|||:|..|..|.||||||||.    :|.....||:||||||
Human   261 QNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKE----KESPDGNNVACILTLP 321

  Fly   675 PYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDV 739
            ||||:|||:.||.|||.|:::|..:|||||||||||.:||||||..|||:.|.:..| |::|||:
Human   322 PYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRG-TLSIKDL 385

  Fly   740 SQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEY 779
            ||.|:|...||:||||:|.|:|||||:|::.....:::|:
Human   386 SQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEH 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824
		NAT_SF	526..802	CDD:302625	141/254 (56%)
		MOZ_SAS	584..766	CDD:280097	115/181 (64%)
KAT8	NP_892003.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		PLN00104	15..429	CDD:215056	160/365 (44%)
		Tudor-knot	55..111	CDD:288553	9/44 (20%)
		NAT_SF	160..427	CDD:302625	143/271 (53%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:21217699, ECO:0000269\|Ref.22	317..319		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:21217699, ECO:0000269\|Ref.22	324..330		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820