DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and KAT6A

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_011542958.1	Gene:	KAT6A / 7994	HGNCID:	13013	Length:	2048	Species:	Homo sapiens

Alignment Length:	875	Identity:	247/875 - (28%)
Similarity:	360/875 - (41%)	Gaps:	263/875 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 AAASAARRKPPASVNKPSNPANKPSNPTQRSANNNTNRSLENGEGKRPSLSSSSNSTDDSMKIVK 190
            |.....::|...|..:..|..:......:::.......|:::|     ::...||...:|.|...
Human    16 AIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDG-----TILKVSNKGLNSYKDPD 75

  Fly   191 NGRKVPLKMASTVRPKQIRGKLPPAKKNGGGPVISSDGSSGSESGSNS---------GDESSS-- 244
            |..::.|.     :|:. .|||...:......:|.......:|||.::         |.:..|
Human    76 NPGRIALP-----KPRN-HGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSAL 134

  Fly   245 --GSESEGSDSSNSYSSQPVKGGAKGKRSGP-----TKIQNSDSEEERKDKANPMRKLTRSLSMR 302
              ||.:.|.......:.:...|..:..:.||     ||..|.|.:|.           ..|||.
Human   135 FGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKES-----------CESLSC- 187

  Fly   303 RTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPV 367
                                           .|..|.|...|.|...|||.|.|..|.:.:
Human   188 -------------------------------LPPVSLLPHEKDKPVAEPIPICSFCLGTKE---- 217

  Fly   368 SPITQTEKKCPIE-----GCDSSGHLS--------------------------------GNLDKH 395
                |..:|.|.|     .|.:|||.|                                .|.|..
Human   218 ----QNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNM 278

  Fly   396 FLPEACPIYHNMSASE---------------CKERANERKL-----------------RNEQRLK 428
            ...::|....:|...:               |:.|...|||                 |.:.|||
Human   279 LFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLK 343

  Fly   429 M-------PVNIV-TAPGNQNTNLKTLSPE------QREFLAKI------RESRAN--FKPANNN 471
            .       |.:.| |.||.......|||.:      :..:|.:|      |:|..:  |......
Human   344 KQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKG 408

  Fly   472 FLDSKVKL----------EKDVTD-------------------------------EDREPNLAG- 494
            .:|...|.          ..:|.|                               ::.|..|.|
Human   409 LIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGS 473

  Fly   495 --LVPDYDLQLFREAQAQASE-----------------------RIEDE-------LKDLPVGK- 526
              ::.:.|::|||:.|.||.:                       |:|::       ||...|.:
Human   474 QEIMTEKDMELFRDIQEQALQTCAVVVMCKQLYWNWISTFTSGIRLEEQRAADGKTLKQQTVPQQ 538

  Fly   527 --GI-----------KYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEK 578
              |:           ..|..|||::..||.||||.:.:||||:|:|||||:|.||.|.:::|.:|
Human   539 KVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKK 603

  Fly   579 CVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVD 643
            |.|.|||.:|||||..:.|::|||.....|||:||||||.|||||||||||||||||::|..||.
Human   604 CGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVK 668

  Fly   644 GCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSD 708
            |||:||||||. ...|:|   ||||||:.||.||||||||.||||||||::.||:.|||||||||
Human   669 GCHLVGYFSKE-KHCQQK---YNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSD 729

  Fly   709 LGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQ 773
            ||.:||.:|||.|:|:.|.:::...|:||.:|:.|.|...||.|||..|.|:.:...:.::::::
Human   730 LGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRRE 794

  Fly   774 DVLDEYEERVKRRGTFPKIDDSCLRWQPFI 803
            .::.::..:::.......:|..||||.|.|
Human   795 KLIQDHMAKLQLNLRPVDVDPECLRWTPVI 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	10/62 (16%)
		NAT_SF	526..802	CDD:302625	144/289 (50%)
		MOZ_SAS	584..766	CDD:280097	109/181 (60%)
KAT6A	XP_011542958.1	H15	85..162	CDD:197772	14/77 (18%)
		PHD1_MOZ_MORF	205..262	CDD:277090	14/64 (22%)
		PHD2_KAT6A_6B	264..310	CDD:277002	4/45 (9%)
		NAT_SF	549..823	CDD:302625	143/277 (52%)
		MOZ_SAS	609..787	CDD:280097	109/181 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820