DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and Kat6b

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_038949635.1	Gene:	Kat6b / 688634	RGDID:	1566399	Length:	2039	Species:	Rattus norvegicus

Alignment Length:	903	Identity:	273/903 - (30%)
Similarity:	413/903 - (45%)	Gaps:	141/903 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ESGSSSTSGSTSSETGSSSDTDSSSATPE--------EKPSTNSSAKSQTQTQQQTNSGNAQRRK 67
            |..|.|:..|......|.||...::..|.        .|.:.|:....:...|.:.|:|::..|
  Rat   120 EEPSGSSLKSIEKYLRSQSDLTGTTDHPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNTGSSDGR- 183

  Fly    68 PVPAASEDKPK-PSVAPSSKKVNNPPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAA 131
                   ..|: ||..|||.    ||.|.|..:.|  :..|.|....|..:|:.        .:.
  Rat   184 -------GAPQYPSAFPSSL----PPVSLLPHEKD--QPRADPIPICSFCLGTK--------ESN 227

  Fly   132 RRKPP------ASVNKPSNPANKPSNPTQRSANNNTNR---------SLENGEGKRPSLSSSSNS 181
            |.|.|      |......:|:.....| :.:||....|         |....:||........:|
  Rat   228 REKKPEELVSCADCGSSGHPSCLKFCP-ELTANVKALRWQCIECKTCSACRVQGKNADNMLFCDS 291

  Fly   182 TDDSMKI----------------------VKNGRKVPLKMASTVRPKQIR--GKLPPAKKNGGGP 222
            .|....:                      .|.|||:..:.|:.::.:..:  |:.....|.....
  Rat   292 CDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLS 356

  Fly   223 VISSDGSSGSESGSNS---GDES------SSGSESEGSDSSNSYS-SQPVKGGAKGK-RSGPTKI 276
            |.|.:||..:.:|..|   |.::      |||..:.|.|||:..: :.|.:.||..| .:..|.|
  Rat   357 VTSDEGSVNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKTTTSSTYI 421

  Fly   277 QNSDSEEERKDKA-----------NPMRKLTR------SLSMR-RTKQQPKQETDSE--SDGDLE 321
            ..|..:..:|.|.           :|..:.:|      |...| |.|...||...|.  :.|..:
  Rat   422 SASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHMLATGTTQ 486

  Fly   322 DDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSP-----ITQTEKKCPIEG 381
                .:...|:..|.|:.::......::.....||....|..||...|     |..::.|...:|
  Rat   487 ----KLKPPPSALPPPAPISGQSPSSQKSSTSTSSAPTQSSSSRSSEPSFSSLINSSQLKALFDG 547

  Fly   382 CDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKL---RNEQRLKMPVNIVTAPGNQNTN 443
            ........|...|...|...|.......:|....|..:..   :.:.|.:...:...:.|....:
  Rat   548 LSHIYTTQGQSRKKGHPSYAPPKRMRRKTEFSSTAKAKACFFGKRDFRSRFLSHSSCSWGMTRGH 612

  Fly   444 L-KTLSPEQR-EFLAKIRE-SRANFK---------PANNNFLDSKVKLEKD--------VTDEDR 488
            : |.::..:| .||.|.|. .|..:|         |...:..|.::..::|        :..|..
  Rat   613 IFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLADGRINPDQDNDTEIKISIKQESM 677

  Fly   489 EPNLAG---LVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDA 550
            :.|:.|   ||.:.||.:|::||..:.|:||.|......|:....|..|||:::.||.||||.:.
  Rat   678 DVNVMGNKDLVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEY 742

  Fly   551 ARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLL 615
            |||||:|:|||||:|.||:..:.||::||.|.|||.:||||:..|.|::|||...|.|||:||||
  Rat   743 ARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLL 807

  Fly   616 AKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKG 680
            ||.|||||||||||||||||::|..|..|||:||||||. ...|:|   ||||||:.:|.:||:|
  Rat   808 AKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKE-KLCQQK---YNVSCIMIMPQHQRQG 868

  Fly   681 YGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAI 745
            :||.||||||||:|.||:.|||||||||||.:||.:|||.|:|:||.......|:||.:|:.|.:
  Rat   869 FGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHERHISIKAISRATGM 933

  Fly   746 YSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQPFI 803
            ..:||.:|||.|.|:....|:.::::::.::..:.|::|......::|...|||.|.:
  Rat   934 CPHDIATTLQYLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPNEVDPESLRWTPIL 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	5/25 (20%)
		NAT_SF	526..802	CDD:302625	143/275 (52%)
		MOZ_SAS	584..766	CDD:280097	106/181 (59%)
Kat6b	XP_038949635.1	H15	94..168	CDD:197772	10/47 (21%)
		PHD1_MOZ_MORF	213..270	CDD:277090	12/65 (18%)
		PHD2_KAT6A_6B	272..318	CDD:277002	5/45 (11%)
		PLN00104	<721..989	CDD:215056	143/271 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920