DRSC/TRiP Functional Genomics Resources

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Protein Alignment chm and Kat8

DIOPT Version :9

Sequence 1:NP_001260192.1 Gene:chm / 43928 FlyBaseID:FBgn0028387 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_080646.1 Gene:Kat8 / 67773 MGIID:1915023 Length:458 Species:Mus musculus


Alignment Length:387 Identity:165/387 - (42%)
Similarity:233/387 - (60%) Gaps:39/387 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   449 PEQREFLAKIRESRANFKPANNNF----------LDSKV--------KLEKDVTDEDREPNLAGL 495
            |:.....|::.:||.|.:.....|          ||..|        |..||...::.|..|:.|
Mouse    66 PDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSEL 130

  Fly   496 VPDYDLQLFREAQAQASE----------------RIEDELKDLPVGKGIKYISMGKYKMKVWYQS 544
            ....:.::.|..:.:..|                .:|.|.:.:...|.:..|.:|.|::..||.|
Mouse   131 AEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFS 195

  Fly   545 PYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYC 609
            |:|:|..:.||:::||:||:|.|.|...:.|..:|.||.|||.|||||..:.|::||||.:|.||
Mouse   196 PFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYC 260

  Fly   610 QHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLP 674
            |:||||||.||||||||:|||||:|||:|..|..|.||||||||.    :|.....||:||||||
Mouse   261 QNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKE----KESPDGNNVACILTLP 321

  Fly   675 PYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDV 739
            ||||:|||:.||.|||.|:::|..:|||||||||||.:||||||..|||:.|.:..| |::|||:
Mouse   322 PYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRG-TLSIKDL 385

  Fly   740 SQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQP 801
            ||.|:|...||:||||:|.|:|||||:|::.....:::|:.:..:.:.....:|..||:|.|
Mouse   386 SQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAP 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chmNP_001260192.1 zf-C2HC 376..402 CDD:279824
NAT_SF 526..802 CDD:302625 146/276 (53%)
MOZ_SAS 584..766 CDD:280097 115/181 (64%)
Kat8NP_080646.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
PLN00104 21..449 CDD:215056 165/387 (43%)
Sufficient for interaction with KANSL1. /evidence=ECO:0000250|UniProtKB:Q9H7Z6 174..458 146/279 (52%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q9H7Z6 317..319 1/1 (100%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q9H7Z6 324..330 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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