DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and kat6b

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_009305666.1	Gene:	kat6b / 568932	ZFINID:	ZDB-GENE-000607-52	Length:	2044	Species:	Danio rerio

Alignment Length:	764	Identity:	241/764 - (31%)
Similarity:	368/764 - (48%)	Gaps:	143/764 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NPPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPPASVNKPSNPANKPSNPTQ 154
            :||.|::.......:...|..::..|.:..:      ||...||     ..||..|....::||.
Zfish   301 DPPLSRMPKGMWICQVCRPKEQEGKRLLHKT------AAQIKRR-----YAKPGRPRKNLAHPTM 354

  Fly   155 RSANN----NTNRSLENGEGK------RPSLSSSSNSTDDSMKIVKNGRKV--PLKMASTVRPKQ 207
            ..:..    ..:....:|.|.      .||.|:...:||        ||.:  ||....|:.
Zfish   355 SDSGGPGSVELSEKARHGRGSISTFCTPPSSSTFIPTTD--------GRSLTDPLTSTPTLT--- 408

  Fly   208 IRGKLPPAKKNGGGPVISSDGSSGSESGSNSGDESSSGSESEGSDSSNSYSSQPVKGGAKGKRSG 272
               .|||..|...|.:   ||.|...:.|..|..    ...|.|.|||.:  :|.|.|
Zfish   409 ---TLPPINKKTKGLI---DGLSKFFTPSPLGRR----LRGEASGSSNQH--RPRKRG------- 454

  Fly   273 PTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAP 337
                       .||..|:.|              .|....::.|       .::::.||::..:|
Zfish   455 -----------YRKHHASMM--------------TPGVRLNAPS-------SVLLTPSPSQGHSP 487

  Fly   338 SNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGC-DSSGHL---SGNLDKHFLP 398
            .:||.::|.   .|....|...||.:|...| ::.......::|. |...|:   .|...:..||
Zfish   488 ISLNPTQSS---SPSSAHSPHSSSSQSSGPS-LSSLPGNSQLKGLFDGLSHIFTTQGQSRQKGLP 548

  Fly   399 EACPIYHNMSASECKERANERKLRNEQRLKMPV--------NIVTA----PGNQNTNLKTL---- 447
            ...|   .......::.:...|:..:.:.|.||        ::.::    |..:....|:.
Zfish   549 SYAP---PKRVRRTQDMSTSPKMSLQLQGKKPVKGFCSKLASLASSASGWPPKRGRPFKSALHFK 610

  Fly   448 -SPEQRE------FLAKIRESRANFKPANNNFLDSKVK--------LEKDVTDEDREPNLAGLVP 497
             :|..|:      |..|....|.|..|......|.:||        :|:.:..|.:|..:. ||.
Zfish   611 RTPILRKHKLLGRFRFKASPQRENITPGKGRLADGRVKPDPNHAFNVERCLRREPQEGRMT-LVN 674

  Fly   498 DY----DLQLFREA-QAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMY 557
            |:    ||:|||.. :..|.:...|:      |:....|..|||:::.||.||||.:..||||:|
Zfish   675 DHVAEEDLKLFRHVKELTAKKNGGDQ------GQSPPLIEFGKYEIQTWYSSPYPPEYLRLPKLY 733

  Fly   558 ICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDH 622
            :|||||:|.||:..::||::||.|.|||.:|||||..|.|::|||...|.:||:||||||.||||
Zfish   734 LCEFCLKYMKSQDILQRHSKKCGWFHPPANEIYRKDNLSVFEVDGNISKIFCQNLCLLAKLFLDH 798

  Fly   623 KTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLID 687
            |||||||||||||::|..|..|||:||||||. ...|:|   ||||||:.:|.:||:|:||.|||
Zfish   799 KTLYYDVEPFLFYVLTQNDEKGCHLVGYFSKE-KLCQQK---YNVSCIMIMPQFQRQGFGRFLID 859

  Fly   688 FSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAIYSYDIVS 752
            |||||:|:||:.|||||||||||.:||.:|||.|:|:||.|....:::|:.:|:.|.:..:||.:
Zfish   860 FSYLLSRLEGQAGSPEKPLSDLGRLSYLAYWKSVILEYLHNHPDKSVSIRGMSRATGMCPHDIAT 924

  Fly   753 TLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQP 801
            |||.|.|:.:..|:.:::::..:::|:.:|::.:....::|..||.|.|
Zfish   925 TLQQLNMIDFQDGRFVIIQRHQLIEEHMDRLRVKPRLHEVDPDCLSWTP 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	6/29 (21%)
		NAT_SF	526..802	CDD:302625	142/276 (51%)
		MOZ_SAS	584..766	CDD:280097	105/181 (58%)
kat6b	XP_009305666.1	H15	113..167	CDD:197772
		PHD_SF	212..270	CDD:304600
		PHD2_KAT6A_6B	271..317	CDD:277002	3/15 (20%)
		NAT_SF	707..973	CDD:302625	141/269 (52%)
		MOZ_SAS	760..937	CDD:280097	105/180 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010