DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chm and kat8

DIOPT Version :9

Sequence 1:NP_001260192.1 Gene:chm / 43928 FlyBaseID:FBgn0028387 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_001016234.2 Gene:kat8 / 548988 XenbaseID:XB-GENE-969438 Length:465 Species:Xenopus tropicalis


Alignment Length:544 Identity:196/544 - (36%)
Similarity:278/544 - (51%) Gaps:111/544 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 NSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNA 342
            :|.|.||:::..:||.               :|.|.:..|..|  |::.|.:           ..
 Frog     2 DSMSAEEQRNLTSPMN---------------EQGTLASHDDGL--DQLAIKE-----------EE 38

  Fly   343 SKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNM 407
            .:..|....||.|.||     .|......:..:.......|::.|                    
 Frog    39 DEEAVSGGEIGTSGGV-----GRDQEVTVEIGETYLCRRADNTWH-------------------- 78

  Fly   408 SASECKERANERKLRNE------------------QRLKMPVNIVTAPGNQNTN--LKTLSPEQR 452
            ||...:.|.||::.|.|                  .||.:...:..|. .:||:  |..|| ||.
 Frog    79 SAEVIQSRLNEQEGREEYYVHYVGCNRRLDEWVDKNRLALTKTVKDAV-QKNTDQYLNELS-EQP 141

  Fly   453 EFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERIED 517
            |     |:...|.|..:    |....::|  |..:.:|..|.|          |.:.:|..:|  
 Frog   142 E-----RKITRNQKRKH----DEINHVQK--TYAEMDPTTAAL----------EKEHEAITKI-- 183

  Fly   518 ELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWR 582
                    |.:..|.:|.|::..||.||:|:|..:.||:::||:||:|.|.|...:.|...|.||
 Frog   184 --------KYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWVCEYCLKYMKFEKSYRYHLGLCQWR 240

  Fly   583 HPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHI 647
            .|||.||||||.:.|::||||.:|.|||:||||||.||||||||:|||||:|||:|..|..|.||
 Frog   241 QPPGKEIYRKGNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHI 305

  Fly   648 VGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLI 712
            ||||||.    :|.....||:||||||||||:|||:.||.|||.|:::|..:|||||||||||.:
 Frog   306 VGYFSKE----KESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLENTVGSPEKPLSDLGKL 366

  Fly   713 SYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLD 777
            ||||||..|||:.|.:..| |::|||:||.|:|...||:.|||:|.|:|||||:|::.....:::
 Frog   367 SYRSYWSWVLLEILRDFRG-TLSIKDLSQMTSITQNDIIGTLQSLNMVKYWKGQHVICVTPKLVE 430

  Fly   778 EYEERVKRRGTFPKIDDSCLRWQP 801
            |:.:..:.:.....:|...|:|.|
 Frog   431 EHLKSAQYKKPPITVDSINLKWAP 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chmNP_001260192.1 zf-C2HC 376..402 CDD:279824 2/25 (8%)
NAT_SF 526..802 CDD:302625 145/276 (53%)
MOZ_SAS 584..766 CDD:280097 115/181 (64%)
kat8NP_001016234.2 PLN00104 63..456 CDD:215056 177/450 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D285390at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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