DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and kat5b

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_021331810.1	Gene:	kat5b / 503731	ZFINID:	ZDB-GENE-030131-985	Length:	555	Species:	Danio rerio

Alignment Length:	584	Identity:	204/584 - (34%)
Similarity:	295/584 - (50%)	Gaps:	107/584 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 PTKIQNSDSEEE------RKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSP 331
            |...:|.::|:|      ...|..|.|||.....:...|:..:..|...    |:..|:...|..
Zfish    15 PVLRKNQENEDEWPLAEILSVKDIPGRKLYYVHYIDFNKRLDEWVTPDR----LDLKKLQFPKKE 75

  Fly   332 AKKPAPSNLNASK-SKVKRE-----PIGISSGVLSS---------IKSRPVSPITQTEKKCPIEG 381
            ||.|..:.|..|: |..:||     .:.:.|....|         .|:..||..||.....|:..
Zfish    76 AKTPTKNGLPGSRPSSPEREVRKSLDLNVQSASAPSRGKTLPTPKRKAESVSLATQVTAATPVPS 140

  Fly   382 CDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVN------IVTAPGNQ 440
            ..||...|          ...:|..|..|....:|.|   .:||...:..|      |.:.||.:
Zfish   141 LPSSAEAS----------QASVYPAMRDSSFSIKARE---EHEQLTSLTTNGTTRRLIPSQPGRK 192

  Fly   441 NTNLKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDRE------PNLAGLVPDY 499
            ..|  .:..|:   :.|:.:        ||:...|.|.|......:|..      |.:.|
Zfish   193 RKN--CVGTEE---IVKVFQ--------NNSPRSSTVYLPPGEDSQDSSDGIPSAPRMTG----- 239

  Fly   500 DLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLR 564
                     :..|:|..|::  :...|.|..|.:|::::|.||.||||.:...||.:|:|||||:
Zfish   240 ---------SLVSDRSHDDI--ITRMKNIDCIELGRHRLKPWYFSPYPQELTTLPILYLCEFCLK 293

  Fly   565 YQKSETGIKRH-----------------AEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHL 612
            |.||...::||                 ..||..|||||:||||||.:..:::||::.|.|.|:|
Zfish   294 YLKSLKCLQRHLVRAVLGPDVTHSQHQIKTKCNLRHPPGNEIYRKGTISFFEIDGRKNKMYSQNL 358

  Fly   613 CLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQ 677
            |||||.||||||||||.:|||||:||..|..|.||||||||.    :|....|||:|||||||||
Zfish   359 CLLAKCFLDHKTLYYDTDPFLFYVMTEYDSKGFHIVGYFSKE----KESTEDYNVACILTLPPYQ 419

  Fly   678 RKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCN-RSGN----TIAIK 737
            |:|||:|||:|||.|::||||.|:||||||||||:||||||...:|:.|.| :|.|    .:.|.
Zfish   420 RRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMNLKSENGERPQMTIN 484

  Fly   738 DVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQP 801
            ::|:.|::...|::||||.|.::.|:||::|:...:|:::.:|..:.:|..  :||..||.:.|
Zfish   485 EISEITSVKKEDVISTLQYLNLINYYKGQYILTLSEDIVEGHERAMHKRHL--RIDSKCLHFTP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	4/25 (16%)
		NAT_SF	526..802	CDD:302625	146/298 (49%)
		MOZ_SAS	584..766	CDD:280097	108/186 (58%)
kat5b	XP_021331810.1	Tudor-knot	8..66	CDD:314560	12/54 (22%)
kat5b	XP_021331810.1	MOZ_SAS	<243..546	CDD:332306	148/310 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820