DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and enok

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster

Alignment Length:	833	Identity:	254/833 - (30%)
Similarity:	378/833 - (45%)	Gaps:	212/833 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSSSATPEEKPSTN--SSAKSQTQTQQQT-------NSGNAQRRKPVPAASEDKPKPSVAPSSKK 87
            ::...||..|.::|  .|.|.....:..:       |.||.|||| |||:.          ||:|
  Fly   313 EAERMTPSYKYASNKRQSIKKDGNIESPSTSKLCVYNDGNGQRRK-VPASL----------SSRK 366

  Fly    88 VNNPPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPPASVNKPSNPANKPSNP 152
            :|:        .:|::|  .|..:|.|:.:....:    |:...|::..:.::
  Fly   367 MNH--------SEDQFE--FPSKQKRSQILQGGYL----ASQETRKRTFSDLS------------ 405

  Fly   153 TQRSANNNTNRSLENGEGKRPSLSSSSNSTDDSMKIVKNGRKVPLKMASTVRPKQIRGKLPPAKK 217
                                 |.||||.|.|:..:                          ...:
  Fly   406 ---------------------STSSSSESEDEDDE--------------------------DDDR 423

  Fly   218 NGGGPVISSDGSSGSES-GSNSGDESSSGSESEGSDSSNSYSSQPVKGGAKGKRSGPTKIQNSDS 281
            |..|.....|.|:.|:| .|:|.|..||.|.|:.|:..:.|                      |.
  Fly   424 NRNGDDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEY----------------------DE 466

  Fly   282 EEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGD----LEDDKI--------MISKSPAKK 334
            ||:.....:.:|:       :...:..||.....|.||    .:::::        .::|:|...
  Fly   467 EEDYDTDRSTIRE-------KNVFESGKQSCAKLSTGDGLGSPQNNELGSENWGFAAVAKNPIDI 524

  Fly   335 PAPSNLNASKSKVKREPIGISSGVLSSI----------KSRPVSPITQTEKKCPIEGCDSSGHLS 389
            ...|..|   |.||  .||.|....|:.          ||.||:..|..:...||.|.......:
  Fly   525 FVKSKHN---SNVK--GIGYSKPAASTFATSPAANRVQKSTPVASSTPEKNSAPIGGMTIKRQTA 584

  Fly   390 GNLDKHFLP-EACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQRE 453
            ....|..:| ::.|:....|..:|::               .:..:|    :.|.:|....|:.|
  Fly   585 NGQKKKIVPLKSMPLEAGKSYEKCED---------------DIPYLT----EETVMKVQLLEEIE 630

  Fly   454 FLAKIRE--SRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFRE----AQAQAS 512
               :.||  |:|:.|...||..|:..:..|.....:.:|...| |...|::|::|    |..|.|
  Fly   631 ---RSRETHSQADGKREMNNDEDAPGESTKRANPFENQPLPPG-VTATDVELYQEVLHKAVVQMS 691

  Fly   513 ERIEDELKDLPVGKG-----IKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGI 572
            ....:::.|:.:..|     .|.|.:||:.::.||.||:|.:.|||.|:::|||||:|.||.:.:
  Fly   692 NNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVL 756

  Fly   573 KRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIM 637
            .||..||:|:.|||.||:|:|.:.|::|||...|.|||:|||||||||||||||||||||||||:
  Fly   757 DRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYIL 821

  Fly   638 TLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSP 702
            |..|..|||:||||||.....|:    ||||||||:|.|||:||||.||||||||:|.||::|:|
  Fly   822 TKNDQSGCHLVGYFSKEKHCTQK----YNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTP 882

  Fly   703 EKPLSDLGLISYRSYWKDVLLDYLC-NRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGK 766
            ||||||||.:||.||||.|:|:||. :|:...|..||::.:|.:...||....:.|..:|
  Fly   883 EKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIK----- 942

  Fly   767 HIVLKKQDVLDEYEERVK--------------RRGTFPKIDDSCLRWQPFINI 805
               |:|.|....|:..||              ...|...|:..||||.|.:::
  Fly   943 ---LRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSV 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	5/26 (19%)
		NAT_SF	526..802	CDD:302625	147/295 (50%)
		MOZ_SAS	584..766	CDD:280097	108/182 (59%)
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	146/287 (51%)
		MOZ_SAS	768..947	CDD:280097	110/190 (58%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466374
Domainoid	1	1.000	61	1.000	Domainoid score	I2989
eggNOG	1	0.900	-	-		E1_COG5027
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103737
Panther	1	1.100	-	-	P	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750