DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and lsy-12

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001263849.1	Gene:	lsy-12 / 3565873	WormBaseID:	WBGene00045419	Length:	1585	Species:	Caenorhabditis elegans

Alignment Length:	916	Identity:	229/916 - (25%)
Similarity:	376/916 - (41%)	Gaps:	239/916 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SSDTDSSSATPEEKPST---------NSSAKSQTQTQQQTNSGN---------AQRRKPVPAASE 74
            |||.|..| ||..|..|         .:.|.||.......::.|         ..:|:||....:
Worm    12 SSDEDEVS-TPSPKDRTARPTAAARRENVALSQAVALSLEDASNFCSLAFSLERIKREPVDTDYD 75

  Fly    75 D--KPKPSVAPSSKKVNN--PPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAA---AASAAR 132
            |  :|.||..|.|.:.::  |.:.|:.::..||:.........:..:.:..|.|.:   ..|..|
Worm    76 DPNQPGPSSVPVSARTDHVLPIRFKIKAEPQEYDSDEYGKDHGAVQIANKEVPAISPIEEVSQKR 140

  Fly   133 RKPPASVNKPSN----PANKPSNPTQRSANNNTNRSLENGEGKRPSLS-----SSSNSTD----- 183
            |..|...:...:    ..:....|.....|.:.:|.:  |..:.|.:.     :.|:|::
Worm   141 RGRPRKTDAAQHLFFPHVSIKQEPDDGFINFHESRCV--GIAQDPEMQHLHDVNESHSSEIAIFR 203

  Fly   184 DSMKIVKNGRK----VPLKMASTVRPKQIRGKLPPAKKNGGGPVISSDGSSGSESG--------- 235
            ::.||.:..:|    ..|....::..|::.......::....|:|.:  ...:|.|
Worm   204 ETKKITERKKKKTEAEKLWDNMSLTEKEVFQSHTRRRRTTRLPIIQN--FEETEEGCIVEVPIPL 266

  Fly   236 ---SNSGDESSSGSESE---------GSDSSNSYSSQPVKGGAKGKRSGPTKIQNSDS-----EE 283
               .|...||.:|.:.|         .::|::...::..:.....:...|.:||::.|     |.
Worm   267 IDLDNDAVESVTGPQHENVTVSENVLSTESTDQEVTETKRLHDSSRDFNPPRIQDTPSTVIRPEG 331

  Fly   284 ERKD------------------------KANPMRKLTRSLSMRRTKQQPKQETDSE-SDGD--LE 321
            ::||                        .:.|:.:|.|.:            .||| ||.|  |.
Worm   332 DQKDPMSSTSSKRRNTNNSRCASLLSNPHSTPVTRLMRGI------------LDSENSDNDEMLS 384

  Fly   322 DDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSG 386
            :|:..|:|.| :.|.|   ..|....:|....:|:..:.:.:|..::          ::|...|
Worm   385 NDQSEIAKRP-RTPRP---RYSPEAQRRTNSRLSALTIDTNRSNDLN----------VDGSAPS- 434

  Fly   387 HLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNT----NLKTL 447
                               :.||:.|.....:....::||.|         |||:.    .:||.
Worm   435 -------------------SSSAASCGLSTPDPDRTSQQRRK---------GNQSAARSRKIKTP 471

  Fly   448 SPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLV--PDYDL-----QLFR 505
            ||                 |.:..  |..::|:.|....:...||..::  |.|.|     ::|.
Worm   472 SP-----------------PLSQE--DEPMELDSDDDPVNELDNLPIVIDDPSYVLTKEHKEIFE 517

  Fly   506 EAQAQASERIE--------------DELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKM 556
            :.:...|:|.|              .|...||     :.|..|.:.||.||.||:|.:...:.|:
Worm   518 QVKKSVSDRNEFSPAQISEIYRSSKGEQARLP-----ERIHFGAFIMKTWYGSPFPAEFINVKKL 577

  Fly   557 YICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLD 621
            :|||||..|.:|:..::.||:||:.|.|||.||||||.:.|::|||:..|:|||.|||:::.||:
Worm   578 FICEFCFFYARSDEIMQNHAKKCMLRAPPGLEIYRKGDISVFEVDGRLQKEYCQTLCLVSRMFLE 642

  Fly   622 HKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLI 686
            .||::||.|||.|||:|:.|..|||..|||||.    :.:....|:|||:|||.||..|.||.||
Worm   643 SKTVFYDTEPFFFYIVTINDDIGCHFAGYFSKE----KYEPDVNNLSCIMTLPCYQEMGLGRFLI 703

  Fly   687 DFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCN-----RSGNTIAIKDVSQETAIY 746
            |.||.|:|.|...|.||:|||:||..:|..||:..:...|..     ..|:.|:||.::.:|.:.
Worm   704 DISYALSRKEKWFGGPEQPLSELGRKAYGGYWRTTIASCLGRLKDELEFGSGISIKMIADDTGVN 768

  Fly   747 SYDIVSTLQALGMMK---------Y-------WKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDS 795
            .:||:..:.:||..|         |       |....|:|::.:...|         |..:.|..
Worm   769 CHDILEVVCSLGWAKPVDPDEKNHYKLEWDVDWDMVSIILRESEASKE---------TKVQYDPE 824

  Fly   796 CLRWQP 801
            ||.|.|
Worm   825 CLDWVP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	2/25 (8%)
		NAT_SF	526..802	CDD:302625	117/297 (39%)
		MOZ_SAS	584..766	CDD:280097	86/202 (43%)
lsy-12	NP_001263849.1	NAT_SF	550..783	CDD:302625	105/236 (44%)
lsy-12	NP_001263849.1	MOZ_SAS	605..786	CDD:280097	84/184 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920