DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and kat7b

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_997800.1	Gene:	kat7b / 323181	ZFINID:	ZDB-GENE-030131-1901	Length:	568	Species:	Danio rerio

Alignment Length:	639	Identity:	273/639 - (42%)
Similarity:	367/639 - (57%)	Gaps:	105/639 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 KNGRKVPLKMASTVRPKQIRGKLPPAKKNGGGPVISSDGSSGSESGSNSGD-ESSSGSESEGSDS 253
            :.|.|.|.::        |..|....::..|.   ||||::.|:   :||| |.:..|..|.:..
Zfish     4 RKGHKSPFQL--------ILNKPINTERTAGS---SSDGTADSD---DSGDHEKTDSSHGEANQR 54

  Fly   254 SN----------SYSSQ----PVKGGAKGKRSGP-TKIQNSDSEEERKDKANPMRKLTRSLSMRR 303
            :|          |.|||    .:|...:...|.| |...|:.|.|...|.::|......|::
Zfish    55 NNTRMTRASLRLSQSSQDAPPDIKQAVERDESPPRTPTGNAPSSESDIDISSPNASHDESVT--- 116

  Fly   304 TKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVS 368
                 |.:.||.||             |:.:|                           |.|...
Zfish   117 -----KDQKDSGSD-------------PSHRP---------------------------KRRRFH 136

  Fly   369 PITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNI 433
            .......|||..||:|.|||:|..::||....||:|||:||.|||.:|.||:.::|:|.:
Zfish   137 ESYNFNMKCPTPGCNSLGHLTGKHERHFAISGCPLYHNLSADECKVKAIEREKQDEERSQ----- 196

  Fly   434 VTAPGNQN------TNLKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNL 492
                 .||      |..:..:|.|..:..|:.|.|.......:.....|....:......|||.|
Zfish   197 -----GQNEENRHATRHQAPTPRQVRYKEKVIEMRKRRDSGLSKDQKEKYMEHRQTHGTTREPLL 256

  Fly   493 AGLVPDYDLQLFREAQAQASERIEDELKDLPVGKG---IKYISMGKYKMKVWYQSPYPDDAARLP 554
            ..:..||||:|||:|||:|||.:|.......:.:|   ||.|..|:|:::.||.||||::.|||.
Zfish   257 ENITSDYDLELFRKAQARASEDLEKLRLQGQITEGSNMIKTIFFGRYELETWYHSPYPEEYARLG 321

  Fly   555 KMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFF 619
            ::|:|||||:|.||:|.::||..||||:||||||:||||...|::||||:.|.|||:||||||.|
Zfish   322 RLYVCEFCLKYMKSQTILRRHMAKCVWKHPPGDEVYRKGATSVFEVDGKKNKIYCQNLCLLAKLF 386

  Fly   620 LDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSF--YNVSCILTLPPYQRKGYG 682
            ||||||||||||||||:||.||..|||:||||||      |||||  ||||||||:|.|.|:|||
Zfish   387 LDHKTLYYDVEPFLFYVMTEADNTGCHLVGYFSK------EKNSFLNYNVSCILTMPQYMRQGYG 445

  Fly   683 RLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQETAIYS 747
            ::||||||||::||.|:||||:|||||||||||||||:|||.|:.|..|..|:||::|||||:..
Zfish   446 KMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYMYNFKGKEISIKEISQETAVNP 510

  Fly   748 YDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQP 801
            .|||||||:|.|:|||||||:|||:||::|:::.:..:||....||...|:|.|
Zfish   511 VDIVSTLQSLQMLKYWKGKHLVLKRQDLIDDWKAKETKRGNSKTIDPGSLKWTP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	12/25 (48%)
		NAT_SF	526..802	CDD:302625	178/281 (63%)
		MOZ_SAS	584..766	CDD:280097	130/183 (71%)
kat7b	NP_997800.1	zf-C2HC	144..170	CDD:279824	12/25 (48%)
		NAT_SF	287..545	CDD:302625	171/263 (65%)
		MOZ_SAS	351..529	CDD:280097	130/183 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1718
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5134
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1438
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	1	1.000	-	-		FOG0004861
OrthoInspector	1	1.000	-	-		otm25153
orthoMCL	1	0.900	-	-		OOG6_103737
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R755
SonicParanoid	1	1.000	-	-		X2913
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.860