DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and Kat6a

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001094040.1	Gene:	Kat6a / 306571	RGDID:	1304892	Length:	1998	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	242/788 - (30%)
Similarity:	355/788 - (45%)	Gaps:	198/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 NKPSNPANKPSNPTQRSANNNTNR-SLENGEG-------KR--PSLSSSSNSTDDSM-KIVKNGR 193
            ||..|....|.||.:.:.....|. .|:|.:.       ||  ..|:.|..||..|: :.:|:.:
  Rat    65 NKGLNSYKDPDNPGRIALPKPRNHGKLDNKQSVDWNKLLKRAFEGLAESGGSTLKSIERFLKSQK 129

  Fly   194 KVPLKMASTVRP---KQIRGKLPPAKKNG----GGPVISSDGSSGSESGSNSGDESSSGSESEGS 251
            .|......|...   :|:|..:..|..:|    .||:...               ::..:.:||.
  Rat   130 DVSAACGGTAASGFHQQLRLAIKRAVGHGRLLKDGPLYRL---------------NTKAANAEGK 179

  Fly   252 DSSNSYSSQPVKGGAKGKRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSES 316
            :...|.|..|           |..:.   ..|:.|..|.|:...:..|.   ||:|.::
  Rat   180 EGCESLSCLP-----------PVSLL---PHEKDKPVAEPIPICSFCLG---TKEQNRE------ 221

  Fly   317 DGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPI----------- 370
                            |||        :..:.....| :||..|.:|..|...:
  Rat   222 ----------------KKP--------EDLISCADCG-NSGHPSCLKFSPELTVRVRALRWQCIE 261

  Fly   371 TQTEKKCPIEG--------CDSSGHLSGNLDKHFLPEAC-PIYHNMS-----ASECKERANERKL 421
            .:|...|..:|        |||       .|:.|..|.| |....|.     ...|:.|...|||
  Rat   262 CKTCSSCRDQGKNADNMLFCDS-------CDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKL 319

  Fly   422 -----------------RNEQRLKM-------PVNIV-TAPGNQNTNLKTLSPE-----QREFLA 456
                             |.:.|||.       |.:.| |.||.......|:|.:     :..:|.
  Rat   320 LQKKAAQIKRRYANPIGRPKNRLKKQSTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLE 384

  Fly   457 KI------RESRA--NFKPANNNFLD----------------------SKVKLEK---------- 481
            :|      |:|.|  .|.......:|                      |::::.|
  Rat   385 RIDGLDFCRDSSAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEAVDYSELRIRKKGNRKSSTSH 449

  Fly   482 ---DVTD-----EDREPNLAG---LVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGK 535
               |..|     ::.|..|.|   ::.:.|::|||:.|.||.:::.......|..:....|..||
  Rat   450 WPTDNQDGWESKQESEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGK 514

  Fly   536 YKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQV 600
            |::..||.||||.:.:||||:|:|||||:|.||.|.:::|.:||.|.|||.:|||||..:.|::|
  Rat   515 YEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEV 579

  Fly   601 DGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFY 665
            ||.....|||:||||||.|||||||||||||||||::|..||.|||:||||||. ...|:|   |
  Rat   580 DGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKE-KHCQQK---Y 640

  Fly   666 NVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRS 730
            |||||:.||.||||||||.||||||||::.||:.|||||||||||.:||.:|||.|:|:.|.:::
  Rat   641 NVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQN 705

  Fly   731 GNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDS 795
            ...|:||.:|:.|.:...||.|||..|.|:.:...:.::::::.::.::..:::.......:|..
  Rat   706 DKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPE 770

  Fly   796 CLRWQPFI 803
            ||||.|.|
  Rat   771 CLRWTPVI 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	9/34 (26%)
		NAT_SF	526..802	CDD:302625	142/275 (52%)
		MOZ_SAS	584..766	CDD:280097	108/181 (60%)
Kat6a	NP_001094040.1	Required for activation of RUNX1-1. /evidence=ECO:0000250\|UniProtKB:Q92794	1..144		19/78 (24%)
		Required for nuclear localization. /evidence=ECO:0000250	52..166		24/100 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93		5/20 (25%)
		H15	85..162	CDD:197772	17/76 (22%)
		Interaction with PML. /evidence=ECO:0000250	144..662		176/591 (30%)
		PHD1_MOZ_MORF	205..262	CDD:277090	14/90 (16%)
		PHD2_KAT6A_6B	264..310	CDD:277002	12/52 (23%)
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..662		134/353 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..377		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..464		2/23 (9%)
		Catalytic. /evidence=ECO:0000250	486..776		146/293 (50%)
		PLN00104	<502..776	CDD:215056	143/277 (52%)
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	505..808		144/278 (52%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	643..647		3/3 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	652..658		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..947
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1079
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1175
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1195..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1450..1567
		Interaction with PML. /evidence=ECO:0000250	1510..1735
		Interaction with RUNX1-2. /evidence=ECO:0000250	1510..1635
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..1702
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1907..1942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920