DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chm and mst1

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_594630.1	Gene:	mst1 / 2543506	PomBaseID:	SPAC637.12c	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	407	Identity:	154/407 - (37%)
Similarity:	224/407 - (55%)	Gaps:	41/407 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 PEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQREFLAKIRESR 462
            ||.....|....|..:.:|.:|:           ..:|||  ..|...|.|.|:.|......||.
pombe    83 PEKPKKAHGKGKSSKRPKAVDRR-----------RSITAP--SKTEPSTPSTEKPEPSTPSGESD 134

  Fly   463 ANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERIEDELKDLPVGKG 527
            ......|.:.         .:.:||.:|.......:.:...|..:..|....|...       :.
pombe   135 HGSNAGNESL---------PLLEEDHKPESLSKEQEVERLRFSGSMVQNPHEIARI-------RN 183

  Fly   528 IKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRK 592
            |..|.:|.::::.||.||||.:.:.:..:|||.||..|..||...:||.|||..:||||:||||.
pombe   184 INKICIGDHEIEPWYFSPYPKEFSEVDIVYICSFCFCYYGSERQFQRHREKCTLQHPPGNEIYRD 248

  Fly   593 GKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPF 657
            ..:..:::||::.:.:|:::|||:|.|||||.|||||:|||||.|...|..|||:||||||.
pombe   249 DYISFFEIDGRKQRTWCRNICLLSKLFLDHKMLYYDVDPFLFYCMCRRDEYGCHLVGYFSKE--- 310

  Fly   658 LQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVL 722
             :|.:..||::||||||.|||.|||:|||.|||.||:.|.|.||||||||||||||||:||.:.:
pombe   311 -KESSENYNLACILTLPQYQRHGYGKLLIQFSYELTKREHKHGSPEKPLSDLGLISYRAYWAEQI 374

  Fly   723 LDYLCNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYE--ERVKR 785
            ::.:......| .|.:::.:|::.:.|::.|||||.|:||:||:.|:.....:..:||  :..||
pombe   375 INLVLGMRTET-TIDELANKTSMTTNDVLHTLQALNMLKYYKGQFIICISDGIEQQYERLKNKKR 438

  Fly   786 RGTFPKIDDSCLR-WQP 801
            |    :|:...|. |||
pombe   439 R----RINGDLLADWQP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	2/3 (67%)
		NAT_SF	526..802	CDD:302625	131/279 (47%)
		MOZ_SAS	584..766	CDD:280097	96/181 (53%)
mst1	NP_594630.1	SAS2	16..447	CDD:227360	150/401 (37%)
		Tudor-knot	21..74	CDD:288553
		NAT_SF	176..451	CDD:302625	130/290 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910