DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and Kat6a

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001074618.1	Gene:	Kat6a / 244349	MGIID:	2442415	Length:	2003	Species:	Mus musculus

Alignment Length:	780	Identity:	238/780 - (30%)
Similarity:	355/780 - (45%)	Gaps:	184/780 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SVNKPSNPAN----KPSN----PTQRSA--NNNTNRSLENGEGKRPSLSSSSNSTDDSM-KIVKN 191
            |...|.||..    ||.|    .|::|.  |....|:.|       .|:.:..||..|: :.:|:
Mouse    70 SYKDPDNPGRIALPKPRNHGKLDTKQSVDWNKLLKRAFE-------GLAETGGSTLKSIERFLKS 127

  Fly   192 GRKVPLKMASTVRP---KQIRGKLPPAKKNG----GGPVISSDGSSGSESGSNSGDESSSGSESE 249
            .:.|......:..|   :|:|..:..|..:|    .||:...:..:.|               :|
Mouse   128 QKDVSAACGGSAAPGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAAS---------------AE 177

  Fly   250 GSDSSNSYSSQPVKGGAKGKRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDS 314
            |.:...|.|..|           |..:.   ..|:.|..|.|:...:..|.   ||:|.:::
Mouse   178 GKEGCESLSCLP-----------PVSLL---PHEKDKPVAEPIPICSFCLG---TKEQNREK--- 222

  Fly   315 ESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPI 379
                  :.::::..........||.|..|.....|         :.:::.:.:.  .:|...|..
Mouse   223 ------QPEELVSCADCGNSGHPSCLKFSPELTVR---------VKALRWQCIE--CKTCSSCRD 270

  Fly   380 EG--------CDSSGHLSGNLDKHFLPEAC-PIYHNMS-----ASECKERANERKL--------- 421
            :|        |||       .|:.|..|.| |....|.     ...|:.|...|||
Mouse   271 QGKNADNMLFCDS-------CDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIK 328

  Fly   422 --------RNEQRLKM-------PVNIV-TAPGNQNTNLKTLSPE-----QREFLAKI------R 459
                    |.:.|||.       |.:.| |.||.......|:|.:     :..:|.:|      |
Mouse   329 RRYANPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFCR 393

  Fly   460 ESRA--NFKPANNNFLDSKVKL----------EKDVTD--------------------------- 485
            :|.|  .|.......:|...|.          ..:|.|
Mouse   394 DSNAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKKGNRKSSTSDWPTDNQDG 458

  Fly   486 ----EDREPNLAG---LVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQ 543
                ::.|..|.|   ::.:.|::|||:.|.||.:::.......|..:....|..|||::..||.
Mouse   459 WESKQENEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYS 523

  Fly   544 SPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQY 608
            ||||.:.:||||:|:|||||:|.||.|.:::|.:||.|.|||.:|||||..:.|::|||.....|
Mouse   524 SPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIY 588

  Fly   609 CQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTL 673
            ||:||||||.|||||||||||||||||::|..||.|||:||||||. ...|:|   ||||||:.|
Mouse   589 CQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKE-KHCQQK---YNVSCIMIL 649

  Fly   674 PPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKD 738
            |.||||||||.||||||||::.||:.|||||||||||.:||.:|||.|:|:.|.:::...|:||.
Mouse   650 PQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKK 714

  Fly   739 VSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQPFI 803
            :|:.|.:...||.|||..|.|:.:...:.::::::.::.::..:::.......:|..||||.|.|
Mouse   715 LSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 779

Fly 804 803
Mouse 780 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	9/34 (26%)
		NAT_SF	526..802	CDD:302625	142/275 (52%)
		MOZ_SAS	584..766	CDD:280097	108/181 (60%)
Kat6a	NP_001074618.1	Required for activation of RUNX1-1. /evidence=ECO:0000250\|UniProtKB:Q92794	1..144		19/80 (24%)
		Required for nuclear localization. /evidence=ECO:0000250	52..166		24/102 (24%)
		H15	85..162	CDD:197772	18/83 (22%)
		Interaction with PML. /evidence=ECO:0000250	144..663		172/581 (30%)
		PHD1_MOZ_MORF	205..262	CDD:277090	10/79 (13%)
		PHD2_KAT6A_6B	264..310	CDD:277002	12/52 (23%)
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..663		133/354 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..377		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..466		0/26 (0%)
		Catalytic. /evidence=ECO:0000250	487..777		146/293 (50%)
		MOZ_SAS	<503..777	CDD:332306	143/277 (52%)
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	506..809		144/278 (52%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	644..648		3/3 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	653..659		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1438
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1533
		Interaction with PML. /evidence=ECO:0000250	1511..1740
		Interaction with RUNX1-2. /evidence=ECO:0000250	1511..1636
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1546..1568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1631..1707
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1912..1947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820