DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chm and KAT6B

DIOPT Version :9

Sequence 1:NP_001260192.1 Gene:chm / 43928 FlyBaseID:FBgn0028387 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_001357065.1 Gene:KAT6B / 23522 HGNCID:17582 Length:2073 Species:Homo sapiens


Alignment Length:914 Identity:275/914 - (30%)
Similarity:402/914 - (43%) Gaps:194/914 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 SSSDTDSSSATPEEKPSTNSSAKSQTQTQQQTNSGNAQRRKPVPAASEDKPK-PSVAPSSKKVNN 90
            |.||..|::..|..:......||......:....|...|........:..|: ||..|||.    
Human   135 SQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSL---- 195

  Fly    91 PPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPP---------ASVNKPSNPA 146
            ||.|.|..:.|  :..|.|....|..:|:.        .:.|.|.|         .|...||...
Human   196 PPVSLLPHEKD--QPRADPIPICSFCLGTK--------ESNREKKPEELLSCADCGSSGHPSCLK 250

  Fly   147 NKPSNPTQ---------------------RSANN-----NTNRSLENGEGKRPSLSSSSNSTDDS 185
            ..|...|.                     |:|:|     :.:|.. :.|...|.||....    .
Human   251 FCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGF-HMECCDPPLSRMPK----G 310

  Fly   186 MKIV------KNGRKVPLKMASTVRPKQIR--GKLPPAKKNGGGPVISSDGSSGSESGSNS---G 239
            |.|.      |.|||:..:.|:.::.:..:  |:.....|.....|.|.:||..:.:|..|   |
Human   311 MWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGRGSPGRG 375

  Fly   240 DES------SSGSESEGSDSSNSYS-SQPVKGGAKGKRSGPTKIQNSDSEEERKD-KANPMRKLT 296
            .::      |||..:.|.|||:..: :.|.:.||      .|||..:.:...... |.|   |.|
Human   376 QKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGA------TTKITTTSTYISASTLKVN---KKT 431

  Fly   297 RSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSS 361
            :.|....||..........|.|::.|    .||....:...|...:..|.|      :::|....
Human   432 KGLIDGLTKFFTPSPDGRRSRGEIID----FSKHYRPRKKVSQKQSCTSHV------LATGTTQK 486

  Fly   362 IKSRPVS--PITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNE 424
            :|..|.|  |.|      ||.|...|...|........|::       |:|:|...:......|.
Human   487 LKPPPSSLPPPT------PISGQSPSSQKSSTATSSPSPQS-------SSSQCSVPSLSSLTTNS 538

  Fly   425 QRLKMPV----NIVTAPG----------------NQNTNLKTLSPEQREFLAKIRESRANF---- 465
            | ||...    :|.|..|                .:.|.|.:.:..:..|..| |:.|:.|    
Human   539 Q-LKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGK-RDIRSRFISHS 601

  Fly   466 ---------------------------------------------KPANNNFLDSKVKLEKD--- 482
                                                         .|...:..|.::|.::|   
Human   602 SSSSWGMARGSIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDT 666

  Fly   483 -----VTDEDREPNLAG---LVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMK 539
                 :..|..:.|:.|   :|.:.||.:|::||..:.|:||.|......|:....|..|||:::
Human   667 EIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQ 731

  Fly   540 VWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKR 604
            .||.||||.:.|||||:|:|||||:|.||:..:.||::||.|.|||.:||||:..|.|::|||..
Human   732 TWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNM 796

  Fly   605 YKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSC 669
            .|.|||:||||||.|||||||||||||||||::|..|..|||:||||||. ...|:|   |||||
Human   797 SKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKE-KLCQQK---YNVSC 857

  Fly   670 ILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTI 734
            |:.:|.:||:|:||.||||||||:|.||:.|||||||||||.:||.:|||.|:|:||.:.....|
Human   858 IMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHI 922

  Fly   735 AIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRW 799
            :||.:|:.|.:..:||.:|||.|.|:....|:.::::::.::..:.|::|......::|...|||
Human   923 SIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRW 987

  Fly   800 QPFI 803
            .|.:
Human   988 TPIL 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chmNP_001260192.1 zf-C2HC 376..402 CDD:279824 6/25 (24%)
NAT_SF 526..802 CDD:302625 143/275 (52%)
MOZ_SAS 584..766 CDD:280097 106/181 (59%)
KAT6BNP_001357065.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..97
H15 113..167 CDD:197772 7/31 (23%)
PHD1_MOZ_MORF 212..269 CDD:277090 11/64 (17%)
PHD2_KAT6A_6B 271..317 CDD:277002 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..409 13/48 (27%)
Negatively regulates HAT activity 361..717 79/389 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..531 23/111 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..583 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..663 3/23 (13%)
Catalytic 718..1008 144/278 (52%)
PLN00104 <721..989 CDD:215056 143/271 (53%)
Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358 752..1008 127/244 (52%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 856..860 3/3 (100%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 865..871 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1452
BASP1 1435..>1564 CDD:310221
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1484..1538
Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546 1560..2073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1619
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D629545at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.