DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and mys-4

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_492265.1	Gene:	mys-4 / 183194	WormBaseID:	WBGene00007914	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	828	Identity:	210/828 - (25%)
Similarity:	309/828 - (37%)	Gaps:	272/828 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SSSDTDSSSATPEEKPSTNSSAKSQTQTQQQTNSGNAQRRKPVPAASEDKPKPSVAPSSKKVNNP 91
            |:..|..::::||.|  ..|..|:|....|||.|.::.:||.:...|.|....|..|.||
Worm     5 STKPTSKANSSPEGK--AMSPMKTQLLDDQQTPSSSSSKRKNLRKPSTDDTPSSSEPLSK----- 62

  Fly    92 PKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPPASVNKPSNPANKPSNPTQRS 156
             |::|.|.:...||
Worm    63 -KNRLDSTETAEED--------------------------------------------------- 75

  Fly   157 ANNNTNRSLENGEGKRP--SLSSSSNSTDDSMKIVKNGRKVPLKMASTVRPKQIRGKLPPAKKNG 219
             |....|:|::||...|  |........||.          |||..|..:.|....|....|:..
Worm    76 -NTRRRRTLKHGEVALPVCSFCKEDQKADDE----------PLKECSECKAKYHIRKCLRYKEEF 129

  Fly   220 GGPVI--------------SSDGSSGSESGSN--------SGDESSSGSESEGSDSSNSY--SSQ 260
            ...::              |..|..|..|...        .|..:..|....|...|:.|  :..
Worm   130 ATNILKLNKWFCPRCVECDSCKGYIGDPSNIECTFCCRAWHGSCAPKGYSPSGEFDSDWYCIACC 194

  Fly   261 PVKGGAKGKRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDS-ESDGDLEDDK 324
            .|||         .||.::.|...|...:.|:::       |:||:......|. |.:||:::.|
Worm   195 RVKG---------IKIWHTTSISHRSHPSAPVKE-------RKTKRGGAARKDELEFEGDIDELK 243

  Fly   325 IMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSGHLS 389
            .::               :|..:..|.:...:| .||.|..|.:|
Worm   244 DLL---------------AKRDLTFEILNYEAG-FSSKKPLPYTP-------------------- 272

  Fly   390 GNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQREF 454
                                                         |:.|.:|...:..||.:.||
Worm   273 ---------------------------------------------TSSGKKNKKKQQKSPVREEF 292

  Fly   455 LAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERI---- 515
                                       |.::.:|.|:...:| ..||:||:..:::|.::.
Worm   293 ---------------------------DYSNAERSPDFPKVV-RADLELFKATKSEAYQQTPIFN 329

  Fly   516 ---EDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAE 577
               |.:......||..|.|          |.|.|.:.......:|.|:|||.....:..:..|.:
Worm   330 PHPEGQFLHFGTGKACKAI----------YSSAYEEPLHSSAHLYACKFCLHTTNLKEDLIVHWD 384

  Fly   578 KCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADV 642
            .|..:||||.||||...|..::|||...|:|||.|||::|.|:..||||.:||.|.||::.....
Worm   385 ICNAKHPPGTEIYRNDGLAFFEVDGAVQKKYCQDLCLISKLFIASKTLYDEVETFKFYVLCEITT 449

  Fly   643 DGCHIVGYFSKHIPFLQEKN--SFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKP 705
            :|..|||||||      |||  ...|:||:|.||..|:.||||||||.||.|:|:|.:||.||.|
Worm   450 EGYVIVGYFSK------EKNPSKNNNLSCLLVLPMVQKMGYGRLLIDMSYELSRLEMRIGHPEHP 508

  Fly   706 LSDLGLISYRSYWKDVLLDYLC-NRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIV 769
            |||||:::||.||:..||.|:. :|:.:.:.|||:...|.|...|||:.|....|        ||
Worm   509 LSDLGILAYRGYWRSSLLCYIREHRNYDRLNIKDMCLATRIAPVDIVNQLMLDNM--------IV 565

  Fly   770 LKKQDVLDEYEERV-KRRGTFPK-------IDDSCLRWQPFINIQPSS 809
            ||.    ..|..:: ||...||.       :|.|.|.|:|    :||:
Worm   566 LKG----GVYSIKIGKRALKFPLSQCRRRFVDPSQLFWKP----KPSA 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	0/25 (0%)
		NAT_SF	526..802	CDD:302625	115/286 (40%)
		MOZ_SAS	584..766	CDD:280097	88/184 (48%)
mys-4	NP_492265.1	PLN00058	35..117	CDD:177689	27/149 (18%)
		PHD	92..144	CDD:214584	10/61 (16%)
		PHD	147..193	CDD:214584	9/45 (20%)
		NAT_SF	347..603	CDD:302625	114/287 (40%)
		MOZ_SAS	391..565	CDD:280097	88/187 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I2220
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.970