DRSC/TRiP Functional Genomics Resources

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Protein Alignment chm and KAT7

DIOPT Version :9

Sequence 1:NP_001260192.1 Gene:chm / 43928 FlyBaseID:FBgn0028387 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_008998.1 Gene:KAT7 / 11143 HGNCID:17016 Length:611 Species:Homo sapiens


Alignment Length:644 Identity:286/644 - (44%)
Similarity:378/644 - (58%) Gaps:91/644 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 LPPAKKNGGGPVISSDGSSGSESGSNSGDESSSGSESEGSD-------------SSNSYSSQPVK 263
            :|..|:|.|.   ||||:..|:..::.  |.:..|||:|:.             |.:|..|.||:
Human     1 MPRRKRNAGS---SSDGTEDSDFSTDL--EHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVR 60

  Fly   264 G----GAKGKRSGPTKIQNSDSEEER-KDKANPMRKLTRS----------LSMRRTK-------Q 306
            .    |.:.......::..|..:... ..|..|:|: |||          .|.|.||       .
Human    61 NLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQ-TRSSGSETEQVVDFSDRETKNTADHDES 124

  Fly   307 QPKQET----DSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPV 367
            .|:..|    .||||.|:....:...:|.||   ..:|..|.|.:...|           |.|..
Human   125 PPRTPTGNAPSSESDIDISSPNVSHDESIAK---DMSLKDSGSDLSHRP-----------KRRRF 175

  Fly   368 SPITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVN 432
            ........|||..||:|.|||:|..::||....||:|||:||.|||.||..|..:.|:|:     
Human   176 HESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERM----- 235

  Fly   433 IVTAPGNQNTN----LKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEK-----DVTDEDR 488
               ....|:.|    .:..:|.:|:.  :.:|..|..:...|:.| ||.:.||     ......|
Human   236 ---LSHRQDDNNRHATRHQAPTERQL--RYKEKVAELRKKRNSGL-SKEQKEKYMEHRQTYGNTR 294

  Fly   489 EPNLAGLVPDYDLQLFREAQAQASERIEDELKDLPVGKG---IKYISMGKYKMKVWYQSPYPDDA 550
            ||.|..|..:|||.|||.|||:|||.:|.......:.:|   ||.|:.|:|::..||.||||::.
Human   295 EPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY 359

  Fly   551 ARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLL 615
            |||.::|:|||||:|.||:|.::||..||||:|||||||||||.:.|::||||:.|.|||:||||
Human   360 ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLL 424

  Fly   616 AKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSF--YNVSCILTLPPYQR 678
            ||.|||||||||||||||||:||.||..|||::|||||      |||||  ||||||||:|.|.|
Human   425 AKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSK------EKNSFLNYNVSCILTMPQYMR 483

  Fly   679 KGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSGNTIAIKDVSQET 743
            :|||::||||||||::||.|:||||:|||||||||||||||:|||.||.|..|..|:||::||||
Human   484 QGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQET 548

  Fly   744 AIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEY-EERVKRRGTFPKIDDSCLRWQP 801
            |:...|||||||||.|:|||||||:|||:||::||: .:..||..:...:|.|||:|.|
Human   549 AVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTP 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chmNP_001260192.1 zf-C2HC 376..402 CDD:279824 12/25 (48%)
NAT_SF 526..802 CDD:302625 182/282 (65%)
MOZ_SAS 584..766 CDD:280097 132/183 (72%)
KAT7NP_008998.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..173 46/191 (24%)
zf-C2HC 184..212 CDD:396216 14/27 (52%)
PLN00104 <324..609 CDD:215056 182/290 (63%)
acetyl-CoA binding. /evidence=ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAK 475..477 1/1 (100%)
WM-3835 inhibitor binding. /evidence=ECO:0000269|PubMed:31827282, ECO:0007744|PDB:6MAJ 483..488 3/4 (75%)
acetyl-CoA binding. /evidence=ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAK 483..488 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 275 1.000 Domainoid score I1759
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5134
Inparanoid 1 1.050 480 1.000 Inparanoid score I1474
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D285390at33208
OrthoFinder 1 1.000 - - FOG0004861
OrthoInspector 1 1.000 - - oto88599
orthoMCL 1 0.900 - - OOG6_103737
Panther 1 1.100 - - LDO PTHR10615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2913
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.830

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