DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chm and kat6a

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_031755179.1	Gene:	kat6a / 100496520	XenbaseID:	XB-GENE-6076141	Length:	1904	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	237/793 - (29%)
Similarity:	338/793 - (42%)	Gaps:	215/793 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 KRPSLSSSSNSTDDSMKI------------VKNGR--KVPLKMASTVRPKQIRGK--LPPAKKNG 219
            :|||.....|:...|..:            ||:|.  ||..|..::.:.....|:  ||.|.||.
Frog    25 QRPSEERLCNAVSTSHGLDRHTVLEQLELSVKDGTVLKVTNKGQNSYKDPDNPGRLALPKATKNQ 89

  Fly   220 GGP-------VISSDGSSGSESGSNS---------GDESSSGSESEGSDSSNSYSSQPVKGGAKG 268
            |.|       ::.....|..|.|.:|         .....|.|....:.:|:::..|......:.
Frog    90 GRPEGLDWHRLLKRALESLEEPGGSSLKSIERFLRSQRDVSASFGGNTGASSAFHQQLRLAVKRA 154

  Fly   269 KRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAK 333
            ...|            |.:|...:.:|...|:      :.||..:                |.|.
Frog   155 LAHG------------RINKEGSLYQLNAKLA------EGKQGWE----------------SLAS 185

  Fly   334 KPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIE-----GCDSSGHLS---- 389
            .|....|...|.|...|||.|.|..|.:.:|       ..||| |.|     .|.:|||.|
Frog   186 LPPVCLLPHEKDKPVAEPIPICSFCLGTKES-------NREKK-PEELISCADCGNSGHPSCLKF 242

  Fly   390 ----------------------------GNLDKHFLPEACPIYHNMSASE--------------- 411
                                        .|.|.....::|....:|...|
Frog   243 SPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCEPPLTRMPKGMWICQI 307

  Fly   412 CKERANERKL-----------------RNEQRLKMPVNIVT--------APGNQN---------- 441
            |:.|...|||                 |.:.|||...:...        |||...
Frog   308 CRPRKKGRKLLHKKAAQIRRRYTNPIGRPKNRLKKQSSTTNPSFGKGRGAPGRGRKRKLSMCSTS 372

  Fly   442 ------------------------------TNLKTLSPEQREFLAKI------RESRANFKPANN 470
                                          |...|.||:.|:..|:.      |..:...:.:..
Frog   373 SDDDRSSDDHRGCGTSVPFNKKTKGLIDGLTKFFTPSPDGRKARAEALDYSLQRSRKRGPRKSGQ 437

  Fly   471 NFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERI-----EDELKDLPVGKGIKY 530
            ...|::...:..:..||.    .|::.:.::.||::.|.||.:::     .|.....|     ..
Frog   438 ADWDNQEGWDCKLDGEDH----PGMISEKEIALFQDIQEQALQKVGVCGPPDPQVRCP-----SV 493

  Fly   531 ISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKL 595
            |..|||:::.||.||||.:..||||:|:|||||||.||.|.:::|.:||.|.|||.:|||||..|
Frog   494 IEFGKYEIQTWYSSPYPQEYTRLPKLYLCEFCLRYMKSRTMLQQHTKKCNWFHPPANEIYRKDNL 558

  Fly   596 QVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQE 660
            .|::||||....|||:||||||.|||||||||||||||||::|..|..|||:||||||. ...|:
Frog   559 SVFEVDGKVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDSKGCHLVGYFSKE-KHCQQ 622

  Fly   661 KNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDY 725
            |   ||||||:.||.||||||||.||||||||::.||:.|||||||||||.:||.:|||.|:|:.
Frog   623 K---YNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVVLEC 684

  Fly   726 LCNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFP 790
            |.:...:.::||.:::.|.|...||.:||..|.|::....:.::::::..:..:..|::.|....
Frog   685 LHHNREHQLSIKRLTKLTGICPQDIAATLHQLRMLELRGDRVVLVRREQQIQTHMSRLQARPREV 749

  Fly   791 KIDDSCLRWQPFI 803
            ::|...|||.|.|
Frog   750 EVDPEALRWTPVI 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824	10/62 (16%)
		NAT_SF	526..802	CDD:302625	143/275 (52%)
		MOZ_SAS	584..766	CDD:280097	107/181 (59%)
kat6a	XP_031755179.1	H15	100..160	CDD:197772	9/71 (13%)
		PHD1_MOZ_MORF	203..260	CDD:277090	16/64 (25%)
		PHD2_KAT6A_6B	262..308	CDD:277002	5/45 (11%)
		PLN00104	<486..760	CDD:215056	144/282 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010