DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fal and Samhd1

DIOPT Version :9

Sequence 1:	NP_001137974.1	Gene:	fal / 43927	FlyBaseID:	FBgn0028380	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001178672.1	Gene:	Samhd1 / 311580	RGDID:	1308369	Length:	620	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	94/348 - (27%)
Similarity:	154/348 - (44%)	Gaps:	75/348 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLG----LLPWAIDKKADHKRYDHCLGAYKSAQ 62
            :..|.:||.||....:..|::.|.||||:::.|||    :.|     .|.|.|::|.||....|.
  Rat   116 VFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFP-----GASHNRFEHSLGVGYLAG 175

  Fly    63 DHLRAIERNSHYEPKLPDWCRQ--AVEIAALLHDIGHGPMSHAW----------ELVTHHE---- 111
            ..:||:   :..:|:|....|.  .|:||.|.||:||||.||.:          ::...||
  Rat   176 CLVRAL---AEKQPELQISERDMLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPDIKWRHEQGSV 237

  Fly   112 --FDH--EENAMACVDKIFKDALNQELVSLRDDGGGRGVQLIKALILGSS----ENLPFPMLGH- 167
              |:|  ..|.:..|.|      |..||...|      :..||..|:|..    ::..:|..|.
  Rat   238 EMFEHLVNSNELKLVMK------NYGLVPEED------ITFIKEQIMGPPVSPVKDCLWPYKGRP 290

  Fly   168 ---TYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEMDFDDVFLQARI-----SPDGQRIEY 224
               :::::||.|:|.|:|||||||..||...|.|.::  .|:......|||     .....::::
  Rat   291 AKKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN--FDYKRFIKFARICEVDDETRAHKVKH 353

  Fly   225 ---RYADYHRVYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIAPELLSIRSKDPK------- 279
               |..:...:|.:|..|:.||.:|||:.:...:|::......:..|.:....::..|
  Rat   354 ICTREKEVGNLYDMFHTRNCLHRRAYQHKIGNLIDIMITEAFLKADPHVEITGTEGKKFRISTAI 418

  Fly   280 -----WLELTDEYVLNVI-EKDP 296
                 :.:|||...|.:: ..||
  Rat   419 HDMEAFSKLTDNIFLEILYSTDP 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fal	NP_001137974.1	HDc	48..210	CDD:238032	57/189 (30%)
Samhd1	NP_001178672.1	SAM_HD	40..109	CDD:188907
		SAM	43..106	CDD:197735
		YdhJ	114..508	CDD:224004	94/348 (27%)
		HDc	161..334	CDD:238032	57/189 (30%)
		TIM_phosphate_binding	<497..>591	CDD:304361
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426111at33208
OrthoFinder	1	1.000	-	-		FOG0002596
OrthoInspector	1	1.000	-	-		oto96821
orthoMCL	1	0.900	-	-		OOG6_100615
Panther	1	1.100	-	-	LDO	PTHR11373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1701
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750