DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZNF646

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_055514.3	Gene:	ZNF646 / 9726	HGNCID:	29004	Length:	1832	Species:	Homo sapiens

Alignment Length:	978	Identity:	193/978 - (19%)
Similarity:	296/978 - (30%)	Gaps:	367/978 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SASFAACIAAGLKVPRQIMYCITQ-----DTGQPYVLYKDSQDAERNPGAIGATPAQ------WG 59
            ||....|...|:..|.:..|.:.:     .:|    :.:.|::.....|...|.||:      ..
Human   877 SAQPFLCCLCGMIFPGRAGYRLHRRQAHSSSG----MTEGSEEEGEEEGVAEAAPARSPPLQLSE 937

  Fly    60 SEMYPNIQQQAQQ-------HL----------TAQQQQQQQQQNAAQAAAQAA------------ 95
            :|:...:|::.:.       |:          ....::..|.|::...|.:|.
Human   938 AELLNQLQREVEALDSAGYGHICGCCGQTYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEM 1002

  Fly    96 -----------AVAAAAGQPQSPPGGGQEARDNGSGDGRQQQVSPSSSPYPSVQQQQRANGAGDE 149
                       :|:...|..:|..|.|....|:....|.:..:.....|:       |.|..|..
Human  1003 VVDSVLEDIVNSVSGEGGDAKSQEGAGTPLGDSLCIQGGESLLEAQPRPF-------RCNQCGKT 1060

  Fly   150 -----DPMNHQLANQ-------------QNPAPNQNQSSNDPQHSGSN---------AGESGNPH 187
                 ..:||:..:|             .|.|..:|...|.|:..||.         ||.|
Human  1061 YRHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSS---- 1121

  Fly   188 VQQNGGPQNDPGNSFRTPDYYDPRHAAPQGGMLAPPGFPPLHYLNK--GVLPMEQSG------GG 244
             :...||..:.|::       .|:|.|.:|     ||...:..|.:  .|.|:|:..      ..
Human  1122 -ELQVGPIPEGGSN-------KPQHMAEEG-----PGQAEVEKLQEELKVEPLEEVARVKEEVWE 1173

  Fly   245 GGAGGGEAYALPEMLPAQQNGQQNAGPANTNANE-GGAGANGSG-----------GVGGATGASV 297
            .....||... |.:..|::..|..|......:.| .|.....:|           |..|....|.
Human  1174 ETTVKGEEIE-PRLETAEKGCQTEASSERPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSK 1237

  Fly   298 GVGSVGVTSGGRTGNGPGRPHKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDA-------- 354
            |..::......|           :.|:|.|.|:|..|||.|:.:..|..|.|:|.:.
Human  1238 GFSNLMSLKNHR-----------RIHADPRRFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRK 1291

  Fly   355 -----RPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHSGEK--- 411
                 |||.|.:||:.:|....|..|.|.|...: ::||.|.:::..|..|..|.|:||..:
Human  1292 ATREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQ-YSCPTCPKTYSNRMALKDHQRLHSENRRRR 1355

  Fly   412 -------PFACPECGKHFRQKAILNQHVRTHQDV-----------------SPHLIFKNG----- 447
                   ...|..||:.|..:..|.:|:|.|::.                 ..:|....|
Human  1356 AGRSRRTAVRCALCGRSFPGRGSLERHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQL 1420

  Fly   448 ----PHPTLWPSDVPFPGEDNDTK-------------------------GDIAGTGGGY------ 477
                |.|.| ...||.|||.:.:.                         |.:....||:
Human  1421 GGAEPVPHL-EDGVPRPGERSQSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLT 1484

  Fly   478 ---HDEDS-QGTPDGSGG--------MHYPSYFKDGKGQKILP-----------------EVLQH 513
               ..||| ..:|..:|.        .|..|:.......::.|                 .:|.|
Human  1485 RSEEPEDSVHRSPCHAGDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNH 1549

  Fly   514 IGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHT-- 576
                ..|......|.:|.|||........|...||:::.:.||:|||.|.....|..||:.|.
Human  1550 ----NTNKTDRHYCLLCSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARG 1610

  Fly   577 --------------------------------------------------------------NEK 579
                                                                          .|:
Human  1611 HSQVPAQMEEARDPKAGTGEDQVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKER 1675

  Fly   580 PFGCMYCPRFFRQR-TILN--------------------------QHLRIHTGEKPYKCGQCGKD 617
            ||.|..|.|.:|.. ::||                          .|.|.||..|.:.|..|||.
Human  1676 PFRCTQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRHCCSICGKA 1740

  Fly   618 FRQKAILDQHTRTH-QGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNTTKVRRQQQQQHQQQQ 681
            ||..|.|:.|.|.| ..:.||.|  |:|.|.|.                    ||....|||||.
Human  1741 FRTAARLEGHGRVHAPREGPFTC--PHCPRHFR--------------------RRISFVQHQQQH 1783

  Fly   682 QQQ 684
            |::
Human  1784 QEE 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		COG5048	355..666	CDD:227381	102/498 (20%)
		zf-C2H2	357..379	CDD:278523	8/21 (38%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		zf-H2C2_2	371..396	CDD:290200	7/24 (29%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	9/33 (27%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	9/21 (43%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	8/46 (17%)
		zf-H2C2_2	596..620	CDD:290200	12/49 (24%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		zf-H2C2_2	624..650	CDD:290200	11/26 (42%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF646	NP_055514.3	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..47
		C2H2 Zn finger	50..70	CDD:275368
		zf-C2H2	75..97	CDD:333835
		C2H2 Zn finger	77..97	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..200
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..346
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	646..663	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..810
		C2H2 Zn finger	823..843	CDD:275368
		C2H2 Zn finger	850..870	CDD:275368
		C2H2 Zn finger	883..901	CDD:275368	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..931		6/33 (18%)
		C2H2 Zn finger	1054..1074	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1081..1101	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1148		14/61 (23%)
		C2H2 Zn finger	1205..1225	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1232..1252	CDD:275368	3/30 (10%)
		C2H2 Zn finger	1260..1280	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1294		3/19 (16%)
		C2H2 Zn finger	1301..1321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1328..1348	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1366..1386	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1481		17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1529		3/19 (16%)
		C2H2 Zn finger	1533..1552	CDD:275368	2/22 (9%)
		C2H2 Zn finger	1559..1579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1587..1611	CDD:275368	10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1606..1672		1/65 (2%)
		C2H2 Zn finger	1679..1699	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1706..1726	CDD:275368	2/19 (11%)
		zf-H2C2_2	1718..1743	CDD:372612	10/24 (42%)
		C2H2 Zn finger	1734..1754	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1832		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910