DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZNF479

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001357058.1	Gene:	ZNF479 / 90827	HGNCID:	23258	Length:	524	Species:	Homo sapiens

Alignment Length:	345	Identity:	114/345 - (33%)
Similarity:	160/345 - (46%)	Gaps:	50/345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..:.:||..|||.|...|....|..|||..:|:.|.||||.|...::||:|.|.|..|||:||
Human   207 HTREKSYKCKECGKSFNCSSNHTTHKIIHTGEKPYRCEECGKAFSWSANLTRHKRTHTGEKPYTC 271

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGP---- 448
            ..|.::||:.:.|..|.|||:||:|:.|.||||.|...:.|..|.|.|....|....:.|.
Human   272 EECGQAFRRSSALTNHKRIHTGERPYKCEECGKAFSVSSTLTDHKRIHTGEKPCRCEECGKAFSW 336

  Fly   449 ------HPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKIL 507
                  |..:...:.|:..|:                                    .|:...:.
Human   337 SSNLTRHKRIHTREKPYACEE------------------------------------CGQAFSLS 365

  Fly   508 PEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHL 572
            ..:::|..:.....|  ..|..|.::|::.:.|..|..||...|||.|.||||.|...|.||.|.
Human   366 SNLMRHRRIHTGEKP--YTCEECGQDFRRSSALTIHKRIHTGERPYKCEECGKVFSLSSTLTDHK 428

  Fly   573 RIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPF 637
            ||||.|:|:.|..|.:.|...:.|..|.||||||:||.|.:|||.|...:.|.||.|.|.|::|:
Human   429 RIHTGERPYKCEECGKAFSLSSTLTDHKRIHTGERPYTCEECGKAFNCSSTLMQHKRIHTGEKPY 493

  Fly   638 CCPMPNCRRRFATENEVTKH 657
            .|  ..|.:.|...:.:.||
Human   494 KC--EECEQAFKWHSSLAKH 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		COG5048	355..666	CDD:227381	102/313 (33%)
		zf-C2H2	357..379	CDD:278523	10/21 (48%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	10/25 (40%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
ZNF479	NP_001357058.1	KRAB	16..76	CDD:214630
		COG5048	<170..372	CDD:227381	56/200 (28%)
		C2H2 Zn finger	187..207	CDD:275368	114/345 (33%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
		C2H2 Zn finger	243..263	CDD:275368	10/19 (53%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		C2H2 Zn finger	299..319	CDD:275368	9/19 (47%)
		COG5048	<323..479	CDD:227381	52/193 (27%)
		C2H2 Zn finger	327..347	CDD:275368	2/19 (11%)
		C2H2 Zn finger	355..375	CDD:275368	3/55 (5%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		C2H2 Zn finger	411..431	CDD:275368	11/19 (58%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
		zf-H2C2_2	480..503	CDD:338759	9/24 (38%)
		C2H2 Zn finger	495..515	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010