DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF486

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_443084.2	Gene:	ZNF486 / 90649	HGNCID:	20807	Length:	463	Species:	Homo sapiens

Alignment Length:	351	Identity:	116/351 - (33%)
Similarity:	159/351 - (45%)	Gaps:	61/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANE 382
            ||.: |::.:..|.:...|.|.|.||...|.:|.|..:|:.|.||||.|.:.||||.|...|..|
Human   172 HKRR-HTEKKPLKYIEGDKAFNQSSTHTTHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTRE 235

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG 447
            ||:.|..|.:.|:..:....|.:|||||||:.|.||||.|.....|..|...|
Human   236 KPYKCEECGKVFKYFSSFTTHKKIHSGEKPYICEECGKAFMYPYTLTTHKIIH------------ 288

  Fly   448 PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQ 512
                  ..:.|:..::.|.                        ..::|:.....|  ||
Human   289 ------TGEQPYKCKECDK------------------------AFNHPATLSSHK--KI------ 315

  Fly   513 HIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTN 577
            |.|.:|      ..|..|.|.|...:.|.:|..||...:||.|.||||.|.:.||||.|..|||.
Human   316 HTGEKP------YTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAFTRSSHLTMHKIIHTG 374

  Fly   578 EKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMP 642
            |||:.|..|.:.|.....|::|.|.|||||||||.:|||.:...:.|.:|..||.|::|:.|  .
Human   375 EKPYKCEECGKAFTWSAGLHKHRRTHTGEKPYKCEECGKAYTTSSNLTEHKTTHTGEKPYKC--K 437

  Fly   643 NCRRRFATENEVTKHIDNHM--NPNT 666
            .|.:.|...:::.||...|:  .|.|
Human   438 ECGKAFNWSSDLNKHKRIHIGQKPRT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		COG5048	355..666	CDD:227381	103/312 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	4/19 (21%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF486	NP_443084.2	KRAB	13..71	CDD:214630
		KRAB	15..52	CDD:279668
		C2H2 Zn finger	155..176	CDD:275368	2/4 (50%)
		COG5048	188..>463	CDD:227381	111/332 (33%)
		C2H2 Zn finger	188..204	CDD:275368	6/15 (40%)
		C2H2 Zn finger	212..232	CDD:275368	11/19 (58%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	4/19 (21%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		zf-H2C2_2	281..305	CDD:290200	5/65 (8%)
		C2H2 Zn finger	296..316	CDD:275368	5/51 (10%)
		zf-H2C2_2	309..333	CDD:290200	10/37 (27%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	12/23 (52%)
		C2H2 Zn finger	352..372	CDD:275368	11/19 (58%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..417	CDD:290200	14/21 (67%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		zf-H2C2_2	420..444	CDD:290200	8/25 (32%)
		C2H2 Zn finger	436..456	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100