DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF430

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_079465.3	Gene:	ZNF430 / 80264	HGNCID:	20808	Length:	570	Species:	Homo sapiens

Alignment Length:	336	Identity:	122/336 - (36%)
Similarity:	158/336 - (47%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..:.:||..|||.|||.|||..|..|||..:|:.|.||||.|.:.||||.|.|||..|||:.|
Human   255 HTGEKPYKCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRC 319

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTL 452
            ..|.|:|.:.:.|..|..||:||||:.|.||||.|.|.:.|..|...|....|
Human   320 EECGRAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKP------------ 372

  Fly   453 WPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYP-SYFKDGKGQKILPEVLQHIGV 516
                                    |..|:       .|...|. ||....|        :.|.|.
Human   373 ------------------------YKCEE-------CGKAFYRFSYLTKHK--------IIHTGE 398

  Fly   517 RPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPF 581
            :      :.:|..|.|.|...:||.:|..||...:||.|.:|||.|.:.|:||.|..|||.|||:
Human   399 K------FYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHTGEKPY 457

  Fly   582 GCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRR 646
            .|..|.:.|.:...|..|..||:|||||||.:|||.|.|.:.|.:|..||.||..:  ....|.:
Human   458 KCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHIGDTSY--KYLECDK 520

  Fly   647 RFATENEVTKH 657
            .|:..:.:|||
Human   521 AFSQSSTLTKH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	11/19 (58%)
		COG5048	355..666	CDD:227381	106/304 (35%)
		zf-C2H2	357..379	CDD:278523	12/21 (57%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	14/24 (58%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
ZNF430	NP_079465.3	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	202..562	CDD:227381	122/336 (36%)
		C2H2 Zn finger	207..227	CDD:275368
		C2H2 Zn finger	235..255	CDD:275368	122/336 (36%)
		zf-H2C2_2	248..272	CDD:290200	7/16 (44%)
		C2H2 Zn finger	263..283	CDD:275368	11/19 (58%)
		zf-H2C2_2	276..300	CDD:290200	12/23 (52%)
		C2H2 Zn finger	291..311	CDD:275368	12/19 (63%)
		zf-H2C2_2	303..328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		zf-H2C2_2	331..356	CDD:290200	14/24 (58%)
		C2H2 Zn finger	347..367	CDD:275368	9/19 (47%)
		C2H2 Zn finger	375..395	CDD:275368	6/34 (18%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..439	CDD:290200	10/22 (45%)
		C2H2 Zn finger	431..451	CDD:275368	9/19 (47%)
		zf-H2C2_2	443..468	CDD:290200	12/24 (50%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-H2C2_2	472..496	CDD:290200	15/23 (65%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
		C2H2 Zn finger	515..535	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010