DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZXDC

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens

Alignment Length:	888	Identity:	190/888 - (21%)
Similarity:	279/888 - (31%)	Gaps:	278/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PQSPPGGGQEARDNGSGDGRQQQVSPSSSPYPSVQQQQRANGAGDEDP-MNHQLANQQNPAPNQN 167
            |.....|||    :|.|.|..::........|:.::.....|..|..| .....|:..:|.|.::
Human     8 PAPTARGGQ----HGGGPGPLRRAPAPLGASPARRRLLLVRGPEDGGPGARPGEASGPSPPPAED 68

  Fly   168 QSSNDP-------QHSGSNAGESGNPHVQQNGGPQNDPG---NSFRTPDYYDPRHAAPQGGMLAP 222
            .|..|.       .|.|:.|        :..|..:.:||   |....|:......|||.|..:||
Human    69 DSDGDSFLVLLEVPHGGAAA--------EAAGSQEAEPGSRVNLASRPEQGPSGPAAPPGPGVAP 125

  Fly   223 PGFPP------LHYLNKGVLPMEQSGGGGGAGGGEAYALPEMLPAQQNGQQNAGPANTNANEGGA 281
            .|...      |..|::|||.:....|...||.    |.|...|      |.:||:.
Human   126 AGAVTISSQDLLVRLDRGVLALSAPPGPATAGA----AAPRRAP------QASGPST-------- 172

  Fly   282 GANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNKPHSDLRLFKC--LTCGKDFKQKSTL 344
                                            ||             ::|  ..|...|.:|..|
Human   173 --------------------------------PG-------------YRCPEPQCALAFAKKHQL 192

  Fly   345 LQHDRIH---TDARPFPC--SECGKRFRQQSHLTQHLRIHANEKPFTCPY--CSRSFRQRAILNQ 402
            ..|...|   ...|||.|  ..||..|.....|.:||:.|...:||.||.  |.:.|.....|..
Human   193 KVHLLTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKA 257

  Fly   403 HIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVPFPGEDNDTK 467
            |::.|..|..|.|..|.:.|...|.|:.|.|:|  ..|...:|           ..|||
Human   258 HMKGHEQESLFKCEVCAERFPTHAKLSSHQRSH--FEPERPYK-----------CDFPG------ 303

  Fly   468 GDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVRCPICDK 532
                                                                          |:|
Human   304 --------------------------------------------------------------CEK 306

  Fly   533 EFKQKTTLLQHGCIHI-ESRPYPC--PECGKRFRQQSHLTQHLRIHTNEKPFGC--MYCPRFFRQ 592
            .|...:.|..|...|. |...:.|  |.|.|::.:...|..|||.||.|:||.|  ..|...|..
Human   307 TFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTS 371

  Fly   593 RTILNQHLRIHTGEKPYKC--GQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVT 655
            .:.|.:|.|.|..::.:.|  ..|||.|.:...|..|:.||.|.:||.||:..|..||:..:.:.
Human   372 MSKLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLY 436

  Fly   656 KHIDNHMN---------PNTTKVR----RQQQQQHQQQQQQQQQQQQQQQQQNNNAVAQVANHLM 707
            .|...|:.         |.:|..|    :...:.|..:|..::|....|.:..::...
Human   437 IHSKKHVQDVGAPKSRCPVSTCNRLFTSKHSMKAHMVRQHSRRQDLLPQLEAPSSLTP------- 494

  Fly   708 NDAKSLAAQQFLNNNNPSAV--DNKAN-----------------ILPVRSIASNAAAAAVVQQSV 753
            :...|...|..|.|.:.:|:  |..||                 .:.|.|::|:.........|.
Human   495 SSELSSPGQSELTNMDLAALFSDTPANASGSAGGSDEALNSGILTIDVTSVSSSLGGNLPANNSS 559

  Fly   754 VKNELYFPQCYGPPFQHPFQAQQQQAQQPSVAHANGGPTPPVTVTVANSVASGVVVQQNASASVV 818
            :          ||             .:|.|..|:....|.:...:....|:.|:.|.:.|...|
Human   560 L----------GP-------------MEPLVLVAHSDIPPSLDSPLVLGTAATVLQQGSFSVDDV 601

  Fly   819 AQXHPTTAATGAQQQQPSAPQQQHHPPPPPPTSTAHHIASAAAAVTAVTPSSAHASPVAAPQTVT 883
                 .|.:.||.....:.|.:.....|...||.    ::.||.:|..|.||......:.|:.:
Human   602 -----QTVSAGALGCLVALPMKNLSDDPLALTSN----SNLAAHITTPTSSSTPRENASVPELL- 656

  Fly   884 LSITLPPPPASHTVHPGHPGHPGHPGVANGAAPPPPTLSHAIP 926
                     |...|.|..|..||..|...|        ||.:|
Human   657 ---------APIKVEPDSPSRPGAVGQQEG--------SHGLP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	6/21 (29%)
		COG5048	355..666	CDD:227381	82/330 (25%)
		zf-C2H2	357..379	CDD:278523	8/23 (35%)
		C2H2 Zn finger	359..379	CDD:275368	7/21 (33%)
		zf-H2C2_2	371..396	CDD:290200	10/26 (38%)
		C2H2 Zn finger	387..407	CDD:275368	6/21 (29%)
		zf-H2C2_2	400..424	CDD:290200	8/23 (35%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		zf-C2H2	553..575	CDD:278523	8/23 (35%)
		C2H2 Zn finger	555..575	CDD:275368	8/21 (38%)
		C2H2 Zn finger	583..603	CDD:275368	6/21 (29%)
		zf-H2C2_2	596..620	CDD:290200	9/25 (36%)
		C2H2 Zn finger	611..631	CDD:275368	7/21 (33%)
		zf-H2C2_2	624..650	CDD:290200	12/25 (48%)
		C2H2 Zn finger	639..661	CDD:275368	6/21 (29%)
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		30/130 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174		9/72 (13%)
		C2H2 Zn finger	177..199	CDD:275368	6/21 (29%)
		zf-C2H2_aberr	208..353	CDD:293622	48/225 (21%)
		zf-C2H2	208..232	CDD:278523	8/23 (35%)
		C2H2 Zn finger	210..232	CDD:275368	7/21 (33%)
		C2H2 Zn finger	240..262	CDD:275368	6/21 (29%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		COG5048	<284..443	CDD:227381	53/239 (22%)
		C2H2 Zn finger	299..321	CDD:275368	8/89 (9%)
		C2H2 Zn finger	333..352	CDD:275368	7/18 (39%)
		C2H2 Zn finger	360..382	CDD:275368	6/21 (29%)
		zf-H2C2_2	375..401	CDD:290200	9/25 (36%)
		C2H2 Zn finger	390..412	CDD:275368	7/21 (33%)
		COG5048	391..>584	CDD:227381	43/222 (19%)
		C2H2 Zn finger	420..442	CDD:275368	6/21 (29%)
		Required for transcriptional activation	579..688		30/131 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756
		Interaction with CIITA	781..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000