DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF133

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001374224.1	Gene:	ZNF133 / 7692	HGNCID:	12917	Length:	691	Species:	Homo sapiens

Alignment Length:	581	Identity:	168/581 - (28%)
Similarity:	236/581 - (40%)	Gaps:	105/581 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 GGGQEARDNGSGDGRQQQVSP----------SSSPYPSVQQQQ--RANGAGDEDPMNHQLANQQN 161
            |...:.:..|...||::...|          :|.|.|.:....  ....:..:.||.|.|.|  :
Human    78 GNNCDLQKEGKPSGRKKSKKPIEKLKWNSKKNSDPEPELYLDPFCPPGFSSQKFPMQHVLCN--H 140

  Fly   162 P-------APNQNQSSNDP----QHSGSNAGESGNPHVQQNGGPQNDPGNSFRTPDYYDPRHAAP 215
            |       ....|....||    |.....|.| |.|...|..||:.:.....     :.......
Human   141 PPWIFTCLCAEGNIQPGDPGPGDQEKQQQASE-GRPWSDQAEGPEGEGAMPL-----FGRTKKRT 199

  Fly   216 QGGMLAPPGFPPLHYLNKGVLPMEQSGGGGGAGGGEAYALPEMLPAQQNGQQNAGPANTNANEGG 280
            .|....||...|:...|             |..|.|..|.|         .|:..|..|:.....
Human   200 LGAFSRPPQRQPVSSRN-------------GLRGVELEASP---------AQSGNPEETDKLLKR 242

  Fly   281 AGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNKPHSDLRLFKCLTCGKDFKQKSTLL 345
            ....|.|        :|..|..|::....|..   ..|: :.||..:.:.|..|.|.|..|.:|.
Human   243 IEVLGFG--------TVNCGECGLSFSKMTNL---LSHQ-RIHSGEKPYVCGVCEKGFSLKKSLA 295

  Fly   346 QHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHSGE 410
            :|.:.|:..:|..|.|||:.|.::|.|..|.|.|:.|||:.|..|.|.|.|::.|..|.|.||||
Human   296 RHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGE 360

  Fly   411 KPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVPFPGEDNDTKGDIAGTGG 475
            ||:.|.||||.|.||:.:.:|.|||.:           ..|:..||                .|.
Human   361 KPYVCRECGKGFSQKSAVVRHQRTHLE-----------EKTIVCSD----------------CGL 398

  Fly   476 GYHDEDS----QGTPDGSGGMHYPSYFKD-GKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFK 535
            |:.|..:    |.|..|    ..|...|: |:..:....::.|........| || |.:|...|.
Human   399 GFSDRSNLISHQRTHSG----EKPYACKECGRCFRQRTTLVNHQRTHSKEKP-YV-CGVCGHSFS 457

  Fly   536 QKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHL 600
            |.:||:.|...|...:||.|..||:.|..:|||.:|..||:.|||..|..|.|.|.|::.|.:|.
Human   458 QNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQ 522

  Fly   601 RIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKHIDNH 661
            |.|:||||..||:||:.|.||:.|..|.|||.|:||:.|  ..|.|.|:.:..:.:|...|
Human   523 RTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVC--RECGRGFSHQAGLIRHKRKH 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		COG5048	355..666	CDD:227381	113/312 (36%)
		zf-C2H2	357..379	CDD:278523	9/21 (43%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	9/21 (43%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	596..620	CDD:290200	13/23 (57%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		zf-H2C2_2	624..650	CDD:290200	12/25 (48%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF133	NP_001374224.1	KRAB	1..60	CDD:214630
		COG5048	252..661	CDD:227381	127/369 (34%)
		C2H2 Zn finger	253..273	CDD:275368	4/23 (17%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	10/19 (53%)
		C2H2 Zn finger	393..413	CDD:275368	6/35 (17%)
		C2H2 Zn finger	421..441	CDD:275368	3/19 (16%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	8/19 (42%)
		C2H2 Zn finger	533..553	CDD:275368	10/19 (53%)
		C2H2 Zn finger	561..581	CDD:275368	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..664	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5195
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860