DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZNF99

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	365	Identity:	127/365 - (34%)
Similarity:	177/365 - (48%)	Gaps:	51/365 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 RPHKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHA 380
            |.|| ..|:..:.:||..|||.|...|||::|..|||..:|:.|.||||.|:|.||||:|..||.
Human   525 RKHK-IIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHT 588

  Fly   381 NEKPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFK 445
            .|||:.|..|.::|...:.|.:|..||:|:||:.|.||||.|.|.:.|.:|...|....|:...:
Human   589 GEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEE 653

  Fly   446 NGP----------HPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKD 500
            .|.          |..:...:.|:..|:                       .|....|:.:..|
Human   654 CGKAFKWSSHLTRHKVIHTEEKPYKCEE-----------------------CGKAFNHFSALRK- 694

  Fly   501 GKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQ 565
               .||:     |.|.:|      .:|..|.|.|.|.:||.:|..||...:||.|.||||.|:..
Human   695 ---HKII-----HTGKKP------YKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWS 745

  Fly   566 SHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRT 630
            |.||.|..|||.|||..|..|.:.|:..:.|.:|..||||:|||||.:|||.|...:.|.:|...
Human   746 SKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLRKHEII 810

  Fly   631 HQGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNTTKVR 670
            |.|::.:.|  ..|.:.|...:::|.|...||..|...|:
Human   811 HTGEKSYKC--EECGKAFQWSSKLTLHKVIHMERNPANVK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	108/320 (34%)
		zf-C2H2	357..379	CDD:278523	12/21 (57%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		zf-C2H2	553..575	CDD:278523	11/21 (52%)
		C2H2 Zn finger	555..575	CDD:275368	10/19 (53%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	7/25 (28%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	60/182 (33%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..352	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..491	CDD:290200
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368	3/6 (50%)
		zf-H2C2_2	523..548	CDD:290200	10/23 (43%)
		COG5048	534..857	CDD:227381	123/355 (35%)
		C2H2 Zn finger	539..559	CDD:275368	9/19 (47%)
		zf-H2C2_2	552..576	CDD:290200	12/23 (52%)
		C2H2 Zn finger	567..587	CDD:275368	12/19 (63%)
		zf-H2C2_2	579..604	CDD:290200	12/24 (50%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		zf-H2C2_2	607..632	CDD:290200	13/24 (54%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		zf-H2C2_2	636..659	CDD:290200	5/22 (23%)
		C2H2 Zn finger	651..671	CDD:275368	2/19 (11%)
		zf-H2C2_2	663..688	CDD:290200	4/47 (9%)
		C2H2 Zn finger	679..699	CDD:275368	6/51 (12%)
		zf-H2C2_2	691..716	CDD:290200	10/39 (26%)
		C2H2 Zn finger	707..727	CDD:275368	8/19 (42%)
		zf-H2C2_2	720..743	CDD:290200	11/22 (50%)
		C2H2 Zn finger	735..755	CDD:275368	10/19 (53%)
		C2H2 Zn finger	763..783	CDD:275368	5/19 (26%)
		zf-H2C2_2	775..800	CDD:290200	15/24 (63%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	819..839	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000