DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and MZF1

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_005259261.1	Gene:	MZF1 / 7593	HGNCID:	13108	Length:	775	Species:	Homo sapiens

Alignment Length:	792	Identity:	224/792 - (28%)
Similarity:	303/792 - (38%)	Gaps:	234/792 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QDTGQPYVLYKDSQD----AERNPG---------------AIGATPA---------QWGSEMYPN 65
            :|.|...|..:||::    |..:||               |.|...|         ||   :.|.
Human    56 EDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQW---LRPE 117

  Fly    66 IQQQAQ--------QHLTAQQQQQQQQQNAAQAAAQAAAVAAAAGQPQSPPG---------GGQE 113
            ::.:.|        |.|.|...:.|.:....:..:...|.|...|..:.|.|         .|||
Human   118 VRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQE 182

  Fly   114 ARDNGSGDGRQQQVSPSS-SPYPSVQQQQRANG------AGDEDPMNHQLANQQNPAPNQNQSSN 171
            .        ..:::.||| .|.|..:......|      ...|.|:..|:..:.....:.:...:
Human   183 V--------LSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLGLQVKEESEVTEDSDFLES 239

  Fly   172 DP----QHS-----GSNAGESGN------PHVQQNGGPQNDPGNSFR----------TPDYYDPR 211
            .|    |.|     ...|...|.      ||  ...||:   |.|:|          ....:.|.
Human   240 GPLAATQESVPTLLPEEAQRCGTVLDQIFPH--SKTGPE---GPSWREHPRALWHEEAGGIFSPG 299

  Fly   212 HAAPQGGMLAPPG--FPPLHYLNKGVLPMEQSGGGGGAG--------GGEAYALPEMLPAQQNGQ 266
            .|...|.:.|.||  .|.||      :|.: .|..|.:|        ||.|:||  :||:....:
Human   300 FALQLGSISAGPGSVSPHLH------VPWD-LGMAGLSGQIQSPSREGGFAHAL--LLPSDLRSE 355

  Fly   267 QN---------AGPA--NTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKN 320
            |:         .|||  .|........:.|....||           ||..|||
Human   356 QDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGG-----------GVVRGGR----------- 398

  Fly   321 KPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPF 385
                      |..|||.|.|:|.||:|.:|||..|||.|||||:.|.:.|||.:|...|..|:||
Human   399 ----------CDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPF 453

  Fly   386 TCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHP 450
            .|..|.:.|.:.|.|.:|.|:|:||:||.|.|||:.|||::.|.||.|.|.|         .|.|
Human   454 VCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGD---------PPGP 509

  Fly   451 TLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGM-----------------HYPSYF 498
            ...|...|                         |.|:..|..                 |...:.
Human   510 GAKPPAPP-------------------------GAPEPPGPFPCSECRESFARRAVLLEHQAVHT 549

  Fly   499 KD------------GKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESR 551
            .|            |:...:|.....|.|.||      ..|..|.:.|:|::.|.||..||...|
Human   550 GDKSFGCVECGERFGRRSVLLQHRRVHSGERP------FACAECGQSFRQRSNLTQHRRIHTGER 608

  Fly   552 PYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGK 616
            |:.|.||||.|||:..||||||:||.||||.|..|.:.|.||..|.:|.|.|||||||.||:||.
Human   609 PFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEKPYHCGECGL 673

  Fly   617 DFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKHIDNHMN------PNTTKVRRQQQ- 674
            .|.|.:.|.:|.|.|.|:|||.|  |.|.:.|.....:|:|...|..      |...|..||:.
Human   674 GFTQVSRLTEHQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHTGERPYACPECGKAFRQRPT 736

  Fly   675 -QQHQQQQQQQQ 685
             .||.:..::::
Human   737 LTQHLRTHRREK 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	125/345 (36%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	10/24 (42%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	11/19 (58%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	14/21 (67%)
		C2H2 Zn finger	555..575	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	12/25 (48%)
		C2H2 Zn finger	639..661	CDD:275368	6/21 (29%)
MZF1	XP_005259261.1	SCAN	81..193	CDD:128708	21/122 (17%)
		COG5048	399..757	CDD:227381	143/392 (36%)
		C2H2 Zn finger	399..419	CDD:275368	10/19 (53%)
		C2H2 Zn finger	427..447	CDD:275368	10/19 (53%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275370	11/19 (58%)
		C2H2 Zn finger	528..548	CDD:275368	1/19 (5%)
		C2H2 Zn finger	556..576	CDD:275368	2/19 (11%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
		C2H2 Zn finger	612..632	CDD:275368	14/19 (74%)
		C2H2 Zn finger	640..660	CDD:275368	8/19 (42%)
		C2H2 Zn finger	668..688	CDD:275368	9/19 (47%)
		C2H2 Zn finger	696..716	CDD:275368	6/21 (29%)
		C2H2 Zn finger	724..744	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..772	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12427
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010