DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF708

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_016882693.1	Gene:	ZNF708 / 7562	HGNCID:	12945	Length:	587	Species:	Homo sapiens

Alignment Length:	399	Identity:	126/399 - (31%)
Similarity:	185/399 - (46%)	Gaps:	76/399 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..:|:||..|||.|.:.|.|.:|..:||..:|:.|.||||.|:|.|:||.|.:||..|||:.|
Human   246 HTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTNHKKIHTGEKPYKC 310

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGP---- 448
            ..|.::|...:.|..|.|||:||||:.|.||||.|...:.|.:|...|.:..|:...:.|.
Human   311 GECGKAFTLSSHLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNR 375

  Fly   449 ------HPTLWPSDVPFPGEDND---TKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQ 504
                  |..:...:.|:..|:..   ||....    .||
Human   376 SSHLTNHKVIHTGEKPYKCEECGKAFTKSSTL----TYH-------------------------- 410

  Fly   505 KILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLT 569
            |::     |.|.:|      .:|..|.|.|...:.|.:|..||.|.:||.|.||||.|...|:.|
Human   411 KVI-----HTGKKP------YKCEECGKAFSIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFT 464

  Fly   570 QHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGD 634
            .|.:|||.|||:.|..|.:.|...:.|..|..||||||||||.:|||.|.|.:.|.:|...|.|:
Human   465 NHKKIHTGEKPYKCEECGKSFILSSHLTTHKIIHTGEKPYKCKECGKAFNQSSTLMKHKIIHTGE 529

  Fly   635 RPFCCPMPNCRRRFATENEVTKHIDNHMNPNTTKVRRQQQQQHQQQQQQQQQQQQQQQQQNNNAV 699
            :|:.|  ..|.:.|            :.:||.||        |::...:::..:..:...|::..
Human   530 KPYKC--EECGKAF------------NQSPNLTK--------HKRIHTKEKPYKSGRHHSNSDNT 572

  Fly   700 AQVANHLMN 708
            :..:.|.:|
Human   573 SNFSKHKIN 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		COG5048	355..666	CDD:227381	106/323 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	3/21 (14%)
ZNF708	XP_016882693.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010