DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and Zfp715

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001344740.1	Gene:	Zfp715 / 69930	MGIID:	1917180	Length:	886	Species:	Mus musculus

Alignment Length:	876	Identity:	204/876 - (23%)
Similarity:	303/876 - (34%)	Gaps:	285/876 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GQPYVLYKDSQDAERNPGAIGATP------AQWGSEMYP--------------NIQQQAQQHLTA 76
            |..:...|.|:..:|  ||:.|.|      ...|:|..|              |..|:..|||.:
Mouse     5 GFGFATKKTSRTEDR--GAMAADPNFQQKSQPLGAEEQPESCERWMSFEDVTVNFSQEEWQHLDS 67

  Fly    77 QQQQQQQQQNAAQAAAQAAAVAAAAGQPQSPPG------------------GGQEARDNGSGDGR 123
            .|:...|     :...:..:...|.|.....||                  .||..::....|..
Mouse    68 AQRCLYQ-----EVMLEIYSHLLAVGYSIPSPGVIFRMEKGKEAQTAKAEFPGQRCQEKSGNDTL 127

  Fly   124 QQQVSPSSSPYPSVQQQQRANGAGDEDPMNHQLANQQNPAPNQNQSSNDPQHSGSNAGESGNPHV 188
            .|:.|..:|.|.:|..:...:|:.                    .|.......|::..:.|
Mouse   128 PQKASGKTSVYSNVASEVTRDGSW--------------------CSLLQELWQGADITKRG---- 168

  Fly   189 QQNGGPQNDPGNSFRTP-------DYYDPRHAAPQGGML--APPGFPPLHYLNKGVLPMEQSGGG 244
            |||......||:..:..       :|..||...|.|..|  ...|.|..|.|.|.   ::.|.|.
Mouse   169 QQNQILLFPPGSFLKKTLSKNSDHEYQKPRETIPLGPYLISTQEGLPQYHSLPKS---LDVSLGA 230

  Fly   245 GGAGGGEAYALPEMLPAQQ---NGQQNAGPANTNANEGGAGANGSGGV---------GGATGASV 297
            .  |..|...|.:::.:.|   .|..||....|:..|....:.|:|.|         |.......
Mouse   231 N--GHNERDQLIDIVASSQLLIPGSCNANCVVTHGGEESYRSTGNGDVLSHKQPLIYGNRFQVKA 293

  Fly   298 GVGS---------------VGVT--------SGGR----------------------TGNGPGRP 317
            ...|               :.:|        :||:                      ||   |.|
Mouse   294 DQSSQCQEVLYAISLHKPEITLTVDRPIVSYNGGKAFLYVSDSLSHPFQLKVDRVVHTG---GDP 355

  Fly   318 HK-----------------NKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKR 365
            :|                 .:.|::.:|:.|..|||.|...|...:|:.||.:..||.|..|||.
Mouse   356 YKCSSCEKSFCNAAALQQHEQIHTEEKLYVCTLCGKAFSDGSAFYEHELIHKNHTPFICDICGKA 420

  Fly   366 FRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQ 430
            |.::|.||.|.:.|..|||:.|..|.:||:..:.|..|.:||:||||:.|.||||.|.:.|.|..
Mouse   421 FLRKSELTSHKQCHNGEKPYKCNDCEKSFKFPSQLKVHHQIHTGEKPYECRECGKSFSKTAKLKV 485

  Fly   431 HVRTHQDVSPHLIFKNGP----------HPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGT 485
            |.|.|....|::..:.|.          |..|.|.:.|:...|       .|....|..:.....
Mouse   486 HQRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCND-------CGKSFNYPSQLKVHC 543

  Fly   486 PDGSG-------------------GMHYPSY-----FKDGKGQKILPEVLQ-------HIGVRPA 519
            ...:|                   .:||.::     :|..:..|:..::.|       |.|.||
Mouse   544 HSHTGEKPYKCHECGKSFNFPCELKVHYQNHTGEKPYKCRECWKLFSKMSQLKAHYRVHTGERP- 607

  Fly   520 NMPLYVRCPICDKEFK------------------------------------------------- 535
                 .:|..|.|.|.
Mouse   608 -----YKCSHCGKAFSTKEQVQEHERIHTGEKPFVCTECGKAFSSRSSFRKHQLIHTKEKPFVSQ 667

  Fly   536 ------QKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRT 594
                  |:.||:.|..:||..:||.||:|||.|...|.|..|.:|||.|||..|..|.:.|.:.:
Mouse   668 KCETGLQEATLIPHQQLHIGEKPYKCPDCGKLFNYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTS 732

  Fly   595 ILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKHID 659
            .|..|.||||||:||.|..|||.|:|.:.|.:|.:.|..::|:.|..  |.:.|.:.:|:..|:.
Mouse   733 QLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRHEKIHMVEKPYKCSF--CGKSFCSPSELKVHLL 795

  Fly   660 NHMNPN-----------TTKVRRQQQQQHQQ 679
            .|....           .|||   |.|:|::
Mouse   796 IHTGERPYKCSSCWKAFCTKV---QLQEHER 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		COG5048	355..666	CDD:227381	113/417 (27%)
		zf-C2H2	357..379	CDD:278523	10/21 (48%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	8/74 (11%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	7/25 (28%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
Zfp715	NP_001344740.1	KRAB	48..105	CDD:214630	11/61 (18%)
		C2H2 Zn finger	327..350	CDD:275368	1/22 (5%)
		C2H2 Zn finger	358..378	CDD:275368	0/19 (0%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	410..849	CDD:227381	119/432 (28%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		C2H2 Zn finger	470..490	CDD:275368	10/19 (53%)
		C2H2 Zn finger	498..518	CDD:275368	2/19 (11%)
		C2H2 Zn finger	526..546	CDD:275368	3/26 (12%)
		C2H2 Zn finger	554..574	CDD:275368	2/19 (11%)
		C2H2 Zn finger	582..602	CDD:275368	2/19 (11%)
		C2H2 Zn finger	610..630	CDD:275368	4/19 (21%)
		C2H2 Zn finger	638..658	CDD:275368	0/19 (0%)
		C2H2 Zn finger	693..713	CDD:275368	9/19 (47%)
		C2H2 Zn finger	721..741	CDD:275368	6/19 (32%)
		C2H2 Zn finger	749..769	CDD:275368	8/19 (42%)
		C2H2 Zn finger	777..797	CDD:275368	5/21 (24%)
		C2H2 Zn finger	805..825	CDD:275368	6/22 (27%)
		C2H2 Zn finger	833..853	CDD:275368
		C2H2 Zn finger	861..881	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000