DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and Zfp467

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_011239752.1	Gene:	Zfp467 / 68910	MGIID:	1916160	Length:	617	Species:	Mus musculus

Alignment Length:	637	Identity:	169/637 - (26%)
Similarity:	240/637 - (37%)	Gaps:	196/637 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QQQVSPSSSP---YPSVQQQQRANG-------AGDEDP-MNHQLANQQNPAPNQNQSSNDPQH-- 175
            |.:::|.|.|   :.:.|::..:.|       :|.|.| ....:..:|..||.....::.||.
Mouse    40 QPEMAPQSEPRDGFSNAQEKMSSRGESTLHSCSGHETPGQKEGIHTEQAEAPCMGSQASTPQKAE 104

  Fly   176 -SGSNAGE-----------SGNPHVQQNGGPQN-----DPGNSFRTPDYYDPRHAAPQGGMLA-- 221
             :||..||           ......::...||:     .|   |.|||.          |.||
Mouse   105 PAGSVPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSFLPSP---FPTPDL----------GQLAVT 156

  Fly   222 ---PPGFPPLHYLNKGVLPMEQSGGGGGAGGGEAYA----LPE----------------MLPAQQ 263
               .||.|                   ||.||.|.:    :||                .|...|
Mouse   157 YKLEPGTP-------------------GALGGIALSGWAPIPEKPYGCEECERRFRDQLTLRLHQ 202

  Fly   264 NGQQNAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPH---KNKPHSD 325
            ...:..||.                              .....||:..  .|.|   ..:.|..
Mouse   203 RLHRGEGPC------------------------------ACPDCGRSFT--QRAHMLLHQRSHRG 235

  Fly   326 LRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYC 390
            .|.|.|..|.|.|.:|:.|.:|.|.||..||:||:||||||.|:.||..|.:.|..|:||.|..|
Mouse   236 ERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTEC 300

  Fly   391 SRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQ-----------DVSPHLIF 444
            .:.||::..|.:|.|||:||:|:.|.:|.:.|..|..|.:|.|.|.           .|:||
Mouse   301 EKRFRKKTHLIRHQRIHTGERPYQCTQCTRSFTHKQHLVRHQRVHDAASRTRSSPDIPVAPH--- 362

  Fly   445 KNGPHPTLWPS---DVPFP----GEDNDTKGDIAGTGGGYH---------DEDSQGT-------- 485
              .|..:|.||   ..||.    |:....|.::| |....|         ||.:.||
Mouse   363 --SPTASLTPSPPGPKPFACSHCGQSFGWKKNLA-THQSLHLTEGRPFGCDECALGTNVDPAAEP 424

  Fly   486 -------PD---GSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTL 540
                   ||   |||                 |...|    |..:......||.|.:.|.....|
Mouse   425 SACTPHAPDCGPGSG-----------------PAAPQ----RTTSSERSFFCPDCGRGFAHGQHL 468

  Fly   541 LQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTG 605
            .:|..:|...||:.|.:||:||..:.:|..|.|.|:..:||.|..|.|.|.:::.|.:|..:|||
Mouse   469 ARHRRVHTGERPFACAQCGRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTG 533

  Fly   606 EKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKH 657
            .:|:.|..|.:.|..|..|.:|...|.|.|||.|  |.|.:.|:.:..:.:|
Mouse   534 SRPHACAVCARCFSSKTNLVRHQAIHTGSRPFSC--PQCAKSFSRKTHLVRH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		COG5048	355..666	CDD:227381	110/348 (32%)
		zf-C2H2	357..379	CDD:278523	12/21 (57%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	10/24 (42%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	8/21 (38%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	9/23 (39%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
Zfp467	XP_011239752.1	C2H2 Zn finger	185..205	CDD:275368	2/19 (11%)
		COG5048	213..587	CDD:227381	127/402 (32%)
		C2H2 Zn finger	213..233	CDD:275368	4/21 (19%)
		C2H2 Zn finger	241..261	CDD:275368	8/19 (42%)
		C2H2 Zn finger	269..289	CDD:275368	11/19 (58%)
		C2H2 Zn finger	297..317	CDD:275368	7/19 (37%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		C2H2 Zn finger	380..400	CDD:275368	4/20 (20%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910