DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF723

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_024307421.1	Gene:	ZNF723 / 646864	HGNCID:	32286	Length:	547	Species:	Homo sapiens

Alignment Length:	380	Identity:	125/380 - (32%)
Similarity:	172/380 - (45%)	Gaps:	70/380 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:.:..:||..|||.|...|.|..|.||||..:|:.|.||||.|...|.|..|.|||..|||:.|
Human   195 HTRVNCYKCEECGKAFSVPSKLNNHKRIHTGEKPYKCEECGKAFNVSSSLNNHKRIHTGEKPYKC 259

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTL 452
            ..|.::|...:.||.|.|||:||||:.|.||||.|...:.||.|.|.|....|:...:.|.
Human   260 EECGKTFNMFSSLNNHKRIHTGEKPYKCKECGKAFNVFSSLNNHKRIHTGEKPYKCEECGK---- 320

  Fly   453 WPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVR 517
                                                  ..:.||:....|  :|      |.|.:
Human   321 --------------------------------------AFNQPSHLATHK--RI------HTGEK 339

  Fly   518 PANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFG 582
                 || :|..|.|.|.|.:.:..|..||...:||.|.||||.|:...|||.|.||||.|||:.
Human   340 -----LY-KCEECGKAFSQSSHITTHKRIHTGEKPYKCEECGKAFKVSVHLTTHKRIHTGEKPYK 398

  Fly   583 CMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRR 647
            |..|.:.|.|.:.|..|..|||||:||||.||||.|.|.:.|.:|...|..::|:.|  ..|.:.
Human   399 CEECGKAFNQSSALTTHKIIHTGERPYKCKQCGKGFSQSSTLTKHKIIHTKEKPYKC--EECGKA 461

  Fly   648 FATENEVTKHIDNHMNP------------NTTKVRRQQQQQHQQQQQQQQQQQQQ 690
            |...:.:.||...|...            |.:.:..:.:..|.:::.|:.::.::
Human   462 FNQYSTLNKHKIIHAREKPYKCEECGKAFNKSSILNRHKIIHTKEKSQKCEEYEK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	108/322 (34%)
		zf-C2H2	357..379	CDD:278523	10/21 (48%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	16/23 (70%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	7/25 (28%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF723	XP_024307421.1	KRAB	4..64	CDD:214630
		COG5048	156..504	CDD:227381	123/366 (34%)
		C2H2 Zn finger	175..195	CDD:275368	125/380 (33%)
		C2H2 Zn finger	203..223	CDD:275368	9/19 (47%)
		C2H2 Zn finger	231..251	CDD:275368	10/19 (53%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	10/19 (53%)
		C2H2 Zn finger	315..335	CDD:275368	5/69 (7%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	11/19 (58%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		C2H2 Zn finger	455..475	CDD:275368	5/21 (24%)
		C2H2 Zn finger	483..503	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010