DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF695

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_065127.5	Gene:	ZNF695 / 57116	HGNCID:	30954	Length:	515	Species:	Homo sapiens

Alignment Length:	341	Identity:	114/341 - (33%)
Similarity:	151/341 - (44%)	Gaps:	86/341 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 KPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPF 385
            |.|::.:.::|..|||.|...|.|.:|.:|||..:|:.|.||||.|:...:||||.|||:.|||:
Human   260 KNHTEKKTYRCEECGKAFNLCSVLTKHKKIHTGEKPYKCEECGKSFKLFPYLTQHKRIHSREKPY 324

  Fly   386 TCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHP 450
            .|..|.:.|:..:.|.||.|||:|||.|.|.||||.|.|.:.|.:|.|.|....|:
Human   325 KCEECGKVFKLLSYLTQHRRIHTGEKTFRCEECGKAFNQSSHLTEHRRIHTGEKPY--------- 380

  Fly   451 TLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIG 515

Human   381 ----------------------------------------------------------------- 380

  Fly   516 VRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKP 580
                      :|..|.|.|...:.|:||..||...:||.|.||||.|...|:||||.||||.|||
Human   381 ----------KCEECGKAFTWFSYLIQHKRIHTGQKPYKCEECGKAFTWFSYLTQHKRIHTGEKP 435

  Fly   581 FGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCR 645
            :.|..|.:.|...:.|..|.|||||||||||.:|||.|.|.:.|.:|...|..::|:.|  ..|.
Human   436 YKCDECGKAFNWFSYLTNHKRIHTGEKPYKCEECGKAFGQSSHLSKHKTIHTREKPYKC--EECG 498

  Fly   646 RRFATENEVTKHIDNH 661
            :.|....::..|...|
Human   499 KAFNHSAQLAVHEKTH 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		COG5048	355..666	CDD:227381	101/307 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	13/24 (54%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	16/23 (70%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	13/21 (62%)
		C2H2 Zn finger	555..575	CDD:275368	12/19 (63%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	17/23 (74%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	7/25 (28%)
		C2H2 Zn finger	639..661	CDD:275368	4/21 (19%)
ZNF695	NP_065127.5	KRAB	4..76	CDD:214630
		COG5048	148..515	CDD:227381	114/341 (33%)
		C2H2 Zn finger	158..178	CDD:275368
		C2H2 Zn finger	186..206	CDD:275368
		C2H2 Zn finger	214..234	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368	1/1 (100%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		C2H2 Zn finger	298..318	CDD:275368	11/19 (58%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		C2H2 Zn finger	354..374	CDD:275368	10/19 (53%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		C2H2 Zn finger	410..430	CDD:275368	12/19 (63%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		C2H2 Zn finger	494..514	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100