DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZNF253

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_066385.2	Gene:	ZNF253 / 56242	HGNCID:	13497	Length:	499	Species:	Homo sapiens

Alignment Length:	335	Identity:	129/335 - (38%)
Similarity:	167/335 - (49%)	Gaps:	58/335 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:.:.||||:.|||.||:.|||..|.:|||..:|:.|.||||.|.|.::||.|.|||..|||:.|
Human   166 HTGINLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRC 230

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTL 452
            ..|.::|:|.:.|..|.:||:||||:.|.||||.|.:..          |::.|.|...|..|
Human   231 EECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRST----------DLTTHKIVHTGEKP-- 283

  Fly   453 WPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVR 517
                                    |..|:.     |....| ||:....|  ||      |...:
Human   284 ------------------------YKCEEC-----GKAFKH-PSHVTTHK--KI------HTRGK 310

  Fly   518 PANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFG 582
            |.|      |..|.|.||..:.|..|..||...:||.|.||||.|...||||.|..:||.|||:.
Human   311 PYN------CEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYR 369

  Fly   583 CMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRR 647
            |..|.:.|...|.|..|.:||||||||||.:|||.|...:||.:|.|||.|::|:.|  ..|.:.
Human   370 CRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPSILSKHKRTHTGEKPYKC--EECGKS 432

  Fly   648 FATENEVTKH 657
            |...:.:|.|
Human   433 FTASSTLTTH 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	112/303 (37%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	10/25 (40%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
ZNF253	NP_066385.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	146..166	CDD:275368	129/335 (39%)
		COG5048	170..>497	CDD:227381	128/331 (39%)
		C2H2 Zn finger	174..194	CDD:275368	10/19 (53%)
		zf-H2C2_2	187..211	CDD:290200	12/23 (52%)
		C2H2 Zn finger	202..222	CDD:275368	11/19 (58%)
		zf-H2C2_2	214..239	CDD:290200	12/24 (50%)
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		zf-H2C2_2	242..267	CDD:290200	14/24 (58%)
		C2H2 Zn finger	258..278	CDD:275368	9/29 (31%)
		zf-H2C2_2	270..295	CDD:290200	8/55 (15%)
		C2H2 Zn finger	286..306	CDD:275368	8/33 (24%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		zf-H2C2_2	326..350	CDD:290200	11/23 (48%)
		C2H2 Zn finger	342..362	CDD:275368	11/19 (58%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		zf-H2C2_2	383..406	CDD:290200	15/22 (68%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		zf-H2C2_2	411..434	CDD:290200	9/24 (38%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		zf-H2C2_2	439..462	CDD:290200	2/4 (50%)
		C2H2 Zn finger	454..474	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100