DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and zbtb47a

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_683959.6	Gene:	zbtb47a / 556134	ZFINID:	ZDB-GENE-081104-121	Length:	671	Species:	Danio rerio

Alignment Length:	640	Identity:	136/640 - (21%)
Similarity:	207/640 - (32%)	Gaps:	220/640 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 NQQN-PAPNQNQSSNDPQHSGSN------AGES-GNPHVQQNGGPQNDPGNSFRTPDYYDPRHAA 214
            :||| |..|.:.|..|.:.....      .|:| |||:..|....|                  :
Zfish   148 DQQNKPEGNWSDSVKDIKQEKDTTCARICGGKSEGNPYSVQVADLQ------------------S 194

  Fly   215 PQGGMLAPPGFPPLH----------------YLNKGVLPMEQSGGGGGAGGGEAYALPEMLPAQQ 263
            .|||:....|..|.:                .||...|.:.:     |..|..|...|
Zfish   195 VQGGICKVEGKEPRNPEDPDSFNGEQIIVELNLNNQTLNVSK-----GLDGSSAAQSP------- 247

  Fly   264 NGQQNAGPA------------NTNANEGGAGANGS-------------GGVGGATGASVGVGSVG 303
            :|||.:|..            |....|.....:|.             .|.....|.||.:..:.
Zfish   248 SGQQLSGKEKSSDGTFEESRNNVTLEEEEEEEDGEQSEDEDDDDDVRLEGTSEDEGESVFLSEMK 312

  Fly   304 VTSG----GRTGNGPGRPHKNKPHSDLRL-------FKCLTCGKDFKQKSTLLQHDRIHTDARPF 357
            ..:.    .:......|...::..|:.||       |.||.|.|.|..:..|.:|..: |..|..
Zfish   313 SRASAPLVSKRSCARARQETDRDPSEERLDQDGFESFSCLRCPKTFNNRWYLEKHMNV-THNRMC 376

  Fly   358 PCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHSG--EKPFACPECGK 420
            .|.:|||||...|.|..|.:... ||...|..|.::||:...|::|.:|..|  ||.:.|..|.|
Zfish   377 VCEKCGKRFLLDSELLLHQQTDC-EKSIQCLTCGKAFRKLWSLHEHNKIVHGYAEKKYTCEICEK 440

  Fly   421 HFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGT 485
            .|...|.:.:|:..|                  ..::||
Zfish   441 KFYTMAHVRKHMVAH------------------TKEMPF-------------------------- 461

  Fly   486 PDGSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIES 550
                                                    .|..|.|.||:..:|..|...|...
Zfish   462 ----------------------------------------TCETCGKSFKRSMSLKVHSLQHSGE 486

  Fly   551 RPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCG 615
            :|:.|..|.:||:.:..|..|:.||...|.|.|.:|.:.|..:...::|::.|||||||.|..||
Zfish   487 KPFQCEVCSERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICG 551

  Fly   616 KDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNTTKVRRQQQQQHQQQ 680
            |.|..:..:.:|.|||.|::|:.|..  |.:||...|.:..|.:..:
Zfish   552 KSFTSRPNMKRHRRTHTGEKPYPCEA--CGQRFRFSNMLKTHREKCL------------------ 596

  Fly   681 QQQQQQQQQQQQQQNNNAVAQVANHLMNDAKSLAAQQFLNNNNPSAVDNKANILP 735
                                ||.|.|:.|:.::.  ...|.:.|..::...::.|
Zfish   597 --------------------QVRNPLLLDSSTIV--NHTNQDLPGGMETLGDVSP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		COG5048	355..666	CDD:227381	78/312 (25%)
		zf-C2H2	357..379	CDD:278523	9/21 (43%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		zf-H2C2_2	371..396	CDD:290200	7/24 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	10/25 (40%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	6/21 (29%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	4/19 (21%)
		zf-H2C2_2	596..620	CDD:290200	13/23 (57%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	10/25 (40%)
		C2H2 Zn finger	639..661	CDD:275368	6/21 (29%)
zbtb47a	XP_683959.6	BTB	32..137	CDD:279045
		BTB	46..141	CDD:197585
		C2H2 Zn finger	351..370	CDD:275368	7/18 (39%)
		C2H2 Zn finger	378..397	CDD:275368	9/18 (50%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		zf-H2C2_2	447..472	CDD:290200	8/108 (7%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..498	CDD:290200	6/22 (27%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	4/19 (21%)
		zf-H2C2_2	531..556	CDD:290200	13/24 (54%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-H2C2_2	559..582	CDD:290200	8/24 (33%)
		C2H2 Zn finger	575..592	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010