DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and Sall2

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_056587.2	Gene:	Sall2 / 50524	MGIID:	1354373	Length:	1004	Species:	Mus musculus

Alignment Length:	1063	Identity:	197/1063 - (18%)
Similarity:	305/1063 - (28%)	Gaps:	431/1063 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IGATPAQWGSEMYP-----------------NIQQQAQQHLTAQQQQQQQQQNAAQAAAQA---A 95
            :||||....|...|                 ||....::....||:|..|.|...|...|.   .
Mouse   147 LGATPLPPESTPAPPPPPPPPPPPGVGSGHLNIPLILEELRVLQQRQIHQMQMTEQICRQVLLLG 211

  Fly    96 AVAAAAGQPQSP---PGGGQEARDNGSGDGRQQQVSPSSSPYPSVQ-------QQQRANGAGDED 150
            ::....|.|.||   ||.|..:        ..:.:.|..||....|       ....::.:|.|.
Mouse   212 SLGQTVGAPASPSELPGTGAAS--------STKPLLPLFSPIKPAQTGKTLASSSSSSSSSGAEP 268

  Fly   151 P------MNHQLANQQNPAPNQNQSSNDPQHSGSNAGESGNPHVQQNGGPQNDPGNSFRTPDYYD 209
            |      :.|.|.:|.             ..|....|.|..|          .|..|...|...|
Mouse   269 PKQAFFHLYHPLGSQH-------------PFSVGGVGRSHKP----------TPAPSPALPGSTD 310

  Fly   210 PRHAAPQGGMLAPPGFPPLHYLNKGVLPMEQSGGGGGAGGGEAYALPEMLPAQQNGQQNAGPANT 274
            ...|:|.   ||.||       ..|:|..:..   |.|.|.||.|.|.:|..:
Mouse   311 QLIASPH---LAFPG-------TTGLLAAQCL---GAARGLEAAASPGLLKPK------------ 350

  Fly   275 NANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNKPHSDLRLFKCLTCGKDFK 339
                     ||||        .:|.|.| ::|..:    ||..||
Mouse   351 ---------NGSG--------ELGYGEV-ISSLEK----PGGRHK-------------------- 373

  Fly   340 QKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHI 404
                                                           |.:|::.|...:.|..|:
Mouse   374 -----------------------------------------------CRFCAKVFGSDSALQIHL 391

  Fly   405 RIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHP-------TLWPSDVPF--- 459
            |.|:||:|:.|..||..|..:..|..|...|::..||:  :..|||       .:..|.:|:
Mouse   392 RSHTGERPYKCNVCGNRFTTRGNLKVHFHRHREKYPHV--QMNPHPVPEHLDYVITSSGLPYGMS 454

  Fly   460 -PGEDNDTKGDIAGT-GGGYH-------------------------------------------- 478
             |.|..:.:   ||| |||..
Mouse   455 VPPEKAEEE---AGTPGGGVERKPLVASTTALSATESLTLLSTGTSTAVAPGLPTFNKFVLMKAV 516

  Fly   479 ---DEDSQGTPDGSGGMHYPSYFKDGKGQKI--------------------------LPEVLQHI 514
               .:..:.||.||.|.........|...::                          .|.||:.:
Mouse   517 EPKSKADENTPPGSEGSAIAGVADSGSATRMQLSKLVTSLPSWALLTNHLKSTGSFPFPYVLEPL 581

  Fly   515 GVRPANMPLYVRCPICDKEFKQKTTLLQ--------HGCIHIESRPYPCPECGKRFRQQSHLTQH 571
            |..|:                 :|:.||        .|.:.:.|.....|.........|
Mouse   582 GASPS-----------------ETSKLQQLVEKIDRQGAVAVASTASGAPTTSAPAPSSS----- 624

  Fly   572 LRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRP 636
                 ...|..|:.|.|.......|..|...|.||:|:||..||:.|..:..|..|...|: ..|
Mouse   625 -----ASGPNQCVICLRVLSCPRALRLHYGQHGGERPFKCKVCGRAFSTRGNLRAHFVGHK-TSP 683

  Fly   637 FC-----CPMPNCRRRFATENEVTKHIDNHMN---PNTTKV------------------------ 669
            ..     ||:  |:::|.....:.:|:..|:.   ||....
Mouse   684 AARAQNSCPI--CQKKFTNAVTLQQHVRMHLGGQIPNGGSALSEGGGAAQENSSEQSTASGPGSF 746

  Fly   670 -RRQQQQQHQQQQQQQQQQQQQQQQQNNNAVAQVANHLMNDAKSLAAQQFLNNNNPSAVDNKANI 733
             :.|.||...:::..:::::.::::::           :.|..|||.:. ..:....|:..:.:.
Mouse   747 PQPQSQQPSPEEEMSEEEEEDEEEEED-----------VTDEDSLAGRG-SESGGEKAISVRGDS 799

  Fly   734 LPV----RSIASNAAAAAVVQQSVVKNELYFPQCYGPP-------FQHPFQAQQQQAQQPS---- 783
            ..|    ..:|::.||...|:: :..|| ..||...||       ..|| |..:|.....|
Mouse   800 EEVSGAEEEVATSVAAPTTVKE-MDSNE-KAPQHTLPPPPPPPDNLDHP-QPMEQGTSDVSGAME 861

  Fly   784 -VAHANGGPTPPVTVTVANSVASGVVVQQ----------------NASASVVAQXHPTTAATGAQ 831
             .|...|..:|...:|......|..:|::                ..:..|..|..||..|.
Mouse   862 EEAKLEGTSSPMAALTQEGEGTSTPLVEELNLPEAMKKDPGESSGRKACEVCGQSFPTQTAL--- 923

  Fly   832 QQQPSAPQQQHHPPPPPPTS-------------------TAHHIASAAAAVTAVTPSSAHASPVA 877
                 ...|:.||...|..:                   .|||         .|.|.:.|
Mouse   924 -----EEHQKTHPKDGPLFTCVFCRQGFLDRATLKKHMLLAHH---------QVPPFAPH----- 969

  Fly   878 APQTVTLSITLPPPPASHTVHPG 900
            .||.:. :::|.|..:|....||
Mouse   970 GPQNIA-TLSLVPGCSSSIPSPG 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	0/19 (0%)
		COG5048	355..666	CDD:227381	76/411 (18%)
		zf-C2H2	357..379	CDD:278523	0/21 (0%)
		C2H2 Zn finger	359..379	CDD:275368	0/19 (0%)
		zf-H2C2_2	371..396	CDD:290200	3/24 (13%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	4/27 (15%)
		zf-C2H2	553..575	CDD:278523	2/21 (10%)
		C2H2 Zn finger	555..575	CDD:275368	2/19 (11%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	11/23 (48%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..650	CDD:290200	8/30 (27%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
Sall2	NP_056587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..177		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..270		12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..307		6/31 (19%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		zf-H2C2_2	386..411	CDD:290200	11/24 (46%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		C2H2 Zn finger	631..651	CDD:275368	5/19 (26%)
		zf-H2C2_2	643..668	CDD:290200	11/24 (46%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		zf-C2H2	690..711	CDD:278523	5/22 (23%)
		C2H2 Zn finger	691..711	CDD:275368	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..910		32/212 (15%)
		C2H2 Zn finger	910..930	CDD:275368	6/27 (22%)
		zf-C2H2	910..930	CDD:278523	6/27 (22%)
		C2H2 Zn finger	939..957	CDD:275368	0/17 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000