DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF727

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001152994.1	Gene:	ZNF727 / 442319	HGNCID:	22785	Length:	499	Species:	Homo sapiens

Alignment Length:	348	Identity:	118/348 - (33%)
Similarity:	164/348 - (47%)	Gaps:	58/348 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..|.:||..|||..|:.|.|.:|:|:||..:|:.|.||||.|...|.||:|.|.|..::|:.|
Human   194 HTADRSYKCEECGKACKKFSNLTEHNRVHTGKKPYKCEECGKTFTCSSALTKHKRNHTGDRPYKC 258

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTL 452
            ..|.::||..:.|.:|.|||:||||:.|.||.|.||..:.|.:|.|.|....|:
Human   259 EECHKAFRCCSDLTKHKRIHTGEKPYKCKECHKAFRCCSDLTKHKRIHTGEKPY----------- 312

  Fly   453 WPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVR 517
                     :.|:.                                  ||....:..:.||..:.
Human   313 ---------KCNEC----------------------------------GKAFMWISALSQHNRIH 334

  Fly   518 PANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFG 582
            ....| |: |..|.|.|...:||:.|..||:|.|||.|.||||.|:..|.||.|.||||.|||:.
Human   335 TGEKP-YI-CEECGKAFTYSSTLISHKRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTGEKPYK 397

  Fly   583 CMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRR 647
            |..|.:.|...:.|.:|.|||...:||||.:|||.|:....|..|.|.|.|::|:.|  ..|.:.
Human   398 CEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDLTNHKRIHTGEKPYKC--EECGKT 460

  Fly   648 FATENEVTKHIDNHMNPNTTKVR 670
            |...:.:.||..:|.....|..:
Human   461 FTCSSSLIKHKRSHTGDRPTSAK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	103/310 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	9/24 (38%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	13/23 (57%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF727	NP_001152994.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	148..167	CDD:275370
		C2H2 Zn finger	175..194	CDD:275368	118/348 (34%)
		C2H2 Zn finger	202..222	CDD:275368	9/19 (47%)
		zf-H2C2_2	214..239	CDD:290200	12/24 (50%)
		COG5048	<226..409	CDD:227381	78/238 (33%)
		C2H2 Zn finger	230..250	CDD:275368	11/19 (58%)
		zf-H2C2_2	242..267	CDD:290200	9/24 (38%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:290200	14/24 (58%)
		C2H2 Zn finger	286..306	CDD:275368	9/19 (47%)
		zf-H2C2_2	298..321	CDD:290200	8/76 (11%)
		C2H2 Zn finger	314..334	CDD:275368	5/53 (9%)
		zf-H2C2_2	326..351	CDD:290200	8/26 (31%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	11/19 (58%)
		zf-H2C2_2	382..407	CDD:290200	13/24 (54%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		zf-H2C2_2	438..463	CDD:290200	9/26 (35%)
		C2H2 Zn finger	454..474	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010