DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF724

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001342333.1	Gene:	ZNF724 / 440519	HGNCID:	32460	Length:	619	Species:	Homo sapiens

Alignment Length:	419	Identity:	141/419 - (33%)
Similarity:	195/419 - (46%)	Gaps:	53/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GEAYALPEMLPAQQNGQQNAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGP 314
            |:|:.:...|  .|:.:.:.|..:....|.|...|.|..:........|..|......|:..|..
Human   204 GKAFNVSSTL--SQHKRIHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNIS 266

  Fly   315 GRPHKNK-PHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRI 378
            .....:| .|:....:||..|||.|.|.|||.:|..||...:|:.|..||:.|.|.|:||:|.||
Human   267 SHLTTHKIIHTGENAYKCKECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQSSNLTKHKRI 331

  Fly   379 HANEKPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLI 443
            |..:||:.|..|.::|...:.|.||.|||:||||:.|.||||.|...:.|.||.|.|....|:..
Human   332 HTGDKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKC 396

  Fly   444 FKNG----------PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYF 498
            .:.|          .|..:...:.|:..|:          .|...::.||.|.
Human   397 EECGKAFNTSSHLTTHKRIHTGEKPYKCEE----------CGKAFNQFSQLTT------------ 439

  Fly   499 KDGKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFR 563
                 .||:     |.|.:|      .:|..|.|.||:.:.|.:|..||...:||.|.||||.|.
Human   440 -----HKII-----HTGEKP------YKCKECGKAFKRSSNLTEHRIIHTGEKPYKCEECGKAFN 488

  Fly   564 QQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHT 628
            ..||||.|.:|||.|||:.|..|.:.|.|.:.|.:|..||.|||||||.:|||.|.|.:.|.||.
Human   489 LSSHLTTHKKIHTGEKPYKCKECGKAFNQSSTLARHKIIHAGEKPYKCEECGKAFYQYSNLTQHK 553

  Fly   629 RTHQGDRPFCCPMPNCRRRFATENEVTKH 657
            ..|.|::|:.|  ..|.:.|...:.:|||
Human   554 IIHTGEKPYKC--EECGKAFNWSSTLTKH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	113/313 (36%)
		zf-C2H2	357..379	CDD:278523	10/21 (48%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	16/23 (70%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	6/19 (32%)
ZNF724	NP_001342333.1	KRAB	4..64	CDD:214630
		COG5048	143..526	CDD:227381	115/361 (32%)
		C2H2 Zn finger	172..192	CDD:275368
		C2H2 Zn finger	201..220	CDD:275368	4/17 (24%)
		C2H2 Zn finger	228..248	CDD:275368	4/19 (21%)
		C2H2 Zn finger	257..276	CDD:275368	3/18 (17%)
		C2H2 Zn finger	284..304	CDD:275368	10/19 (53%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	368..388	CDD:275368	10/19 (53%)
		C2H2 Zn finger	396..416	CDD:275368	2/19 (11%)
		C2H2 Zn finger	424..444	CDD:275368	7/51 (14%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	11/19 (58%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		SFP1	<530..610	CDD:227516	24/53 (45%)
		C2H2 Zn finger	536..556	CDD:275368	9/19 (47%)
		zf-H2C2_2	548..572	CDD:316026	8/25 (32%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		C2H2 Zn finger	592..612	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010