Protein Alignment jim and ZNF470

DIOPT Version :10

• Sequence 1: NP_001262221.1
• Gene: jim / 43924
• FlyBaseID: FBgn0027339
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001001668.3
• Gene: ZNF470 / 388566
• HGNCID: 22220
• Length: 717
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 133/353 - (37%)
• Similarity: 178/353 - (50%)
• Gaps: 37/353 - (10%)

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..:.::|:.|||.|.|.:.|.||.||||..:||.|:||||.|.|.:||.||.|:|..|||:.|
Human   250 HTGEKPYECIECGKAFSQSAHLAQHQRIHTGEKPFECTECGKAFSQNAHLVQHQRVHTGEKPYQC 314

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGP---- 448
            ..|:::|.|.|.|.||.|:|:||||:.|.||||.|...:.|..|.|.|....|:.....|.
Human   315 KQCNKAFSQLAHLAQHQRVHTGEKPYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQ 379

  Fly   449 ------HPTLW-PSDVPFPGEDNDTKGDIAGTGGGYHDEDS--QGTPDGSGGMHYP-----SYFK 499
                  |...: ..:.||         |....|..:.|...  |.....:|...|.     ..|.
Human   380 NASLIRHRRYYHTGEKPF---------DCIDCGKAFTDHIGLIQHKRTHTGERPYKCNVCGKAFS 435

  Fly   500 DGKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQ 564
            .|....:...:  |.|.:|      ..|.||:|.|..:.:|..|..:|...:||.|.||||.|||
Human   436 HGSSLTVHQRI--HTGEKP------YECNICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQ 492

  Fly   565 QSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTR 629
            .:||..|.||||.|||:.|..|.:.|.|...|.||.:||||||||:|.:|||.|.|.|.|.||.|
Human   493 STHLAHHQRIHTGEKPYECKECSKTFSQNAHLAQHQKIHTGEKPYECKECGKAFSQIAHLVQHQR 557

  Fly   630 THQGDRPFCCPMPNCRRRFATENEVTKH 657
            .|.|::|:.|  ..|.:.|:..:.:.:|
Human   558 VHTGEKPYEC--IECGKAFSDGSYLVQH 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	119/321 (37%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		C2H2 Zn finger	387..407	CDD:275368	9/19 (47%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..575	CDD:275368	12/19 (63%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		C2H2 Zn finger	611..631	CDD:275368	11/19 (58%)
		C2H2 Zn finger	639..661	CDD:275368	4/19 (21%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		Nuclear localization signal. /evidence=ECO:0000255	216..219
		C2H2 Zn finger	230..250	CDD:275368	133/353 (38%)
		COG5048	254..669	CDD:227381	132/349 (38%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		C2H2 Zn finger	286..306	CDD:275368	12/19 (63%)
		C2H2 Zn finger	314..334	CDD:275368	9/19 (47%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		C2H2 Zn finger	370..388	CDD:275368	2/17 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		1/2 (50%)
		C2H2 Zn finger	399..419	CDD:275368	3/19 (16%)
		C2H2 Zn finger	427..447	CDD:275368	2/21 (10%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	12/19 (63%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	11/19 (58%)
		C2H2 Zn finger	567..587	CDD:275368	4/19 (21%)
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:463886
		C2H2 Zn finger	679..699	CDD:275368