DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and Mzf1

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001101940.1	Gene:	Mzf1 / 361508	RGDID:	1308391	Length:	735	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	224/772 - (29%)
Similarity:	302/772 - (39%)	Gaps:	192/772 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 YKDSQDAERNPG---------------AIGATPA---------QWGSEMYPNIQQQAQ-QHLTAQ 77
            |...:|...:||               |||...|         ||   :.|.:..:.| ..|...
  Rat    29 YDKREDTLWDPGPEAARLRFRCFRYEEAIGPQEALAQLRELCHQW---LRPEVHSKEQILELLVL 90

  Fly    78 QQQQQQQQNAAQAAAQAAAVAAAAGQPQSPPGGGQEA-----RDNGSGDGRQ------------- 124
            :|......:..||..|           :..||..:||     |.....||.:
  Rat    91 EQFLGALPSEIQARVQ-----------EQWPGSPEEAAALVDRLRWELDGPRKWVTVQVQGKEVL 144

  Fly   125 -QQVSPSS-SPYPSVQQQ------QRANGAGDEDPMNHQLANQQNPAPNQNQSSNDPQHSGSNAG 181
             :::.||| .|.|.|:.|      :...||..|.|::.|:..:.....|.....::|..:...|.
  Rat   145 SEKMEPSSFQPRPQVKLQTPEAGSETTPGATQELPLDLQMKEETELMENPELLESEPLSAAQEAA 209

  Fly   182 ESGNPHVQQNGG---PQNDPGNSFRTPDY----YDPR---HAAPQGGMLAPPGF----------- 225
            .:..|.|.|..|   .|..| :|...||.    .||.   |...:|  :..|||
  Rat   210 ATLLPKVAQGHGIALDQTSP-HSDTEPDVPPWSEDPMPLWHEEVEG--ILSPGFTLQMDSITAEP 271

  Fly   226 ----PPLHY---LNKGVLPMEQSGGGGGAGGGEAYALP-----EMLPAQQNGQQNAGPANTNANE 278
                |.||.   |:...|..:........|...|..||     |..||.::...:.|||.. |..
  Rat   272 DTVSPHLHVPWDLDMASLSGQMQSPTREGGFAHALVLPSDPGSEQDPACEDPCPSVGPALV-ATR 335

  Fly   279 GGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNKPHSDLRLFKCLTCGKDFKQKST 343
            ..|..:.|.| ..:||       .||..|||                     |..|||.|.|:|.
  Rat   336 WHAPRDRSQG-HPSTG-------TGVMRGGR---------------------CDVCGKVFSQRSN 371

  Fly   344 LLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHS 408
            ||:|.:|||..|||.|.|||:.|.:.|||.:|...|..|:||.|..|.:.|.:.|.|.:|.|:|:
  Rat   372 LLRHQKIHTGERPFVCGECGRSFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEEHRRVHT 436

  Fly   409 GEKPFACPECGKHFRQKAILNQHVRTHQD----VSPHLIFKNGPHPTLWPSDVP-------FPGE 462
            ||:||.|.|||:.|||::.|.||.|.|.|    ..|.......|.|   |...|       ||..
  Rat   437 GEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPAPPVRSLAGVPEP---PGPFPCSECCESFPRR 498

  Fly   463 DNDTKGDIAGTGGGYHDEDSQGTPD-GSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVR 526
            ....:.....||     :.|.|..: |.         :.|:...:|.....|.|.||      ..
  Rat   499 AVLLEHQAVHTG-----DKSFGCVECGE---------RFGRRSVLLQHRRVHSGERP------FA 543

  Fly   527 CPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFR 591
            |..|.:.|:|::.|.||..||...||:.|.||||.|||:..||||||:||.||||.|..|.:.|.
  Rat   544 CAECGQSFRQRSNLTQHRRIHTGERPFACTECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFS 608

  Fly   592 QRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCP---------------- 640
            ||..|.:|.|.|||||||:|.:||..|.|.:.|.:|.|.|.|:|||.||
  Rat   609 QRLKLTRHQRTHTGEKPYRCSECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLIQHR 673

  Fly   641 ----------MPNCRRRFATENEVTKHIDNHMNPNTTKVRRQQQQQHQQQQQQQQQQ 687
                      .|.|.:.|.....:|:|:..|........:...::.||..:..|.|:
  Rat   674 RIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQR 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	126/348 (36%)
		zf-C2H2	357..379	CDD:278523	10/21 (48%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		zf-H2C2_2	371..396	CDD:290200	10/24 (42%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	11/19 (58%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	14/21 (67%)
		C2H2 Zn finger	555..575	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	596..620	CDD:290200	14/23 (61%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	13/51 (25%)
		C2H2 Zn finger	639..661	CDD:275368	7/47 (15%)
Mzf1	NP_001101940.1	SCAN	41..153	CDD:128708	22/125 (18%)
		COG5048	358..717	CDD:227381	140/402 (35%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		C2H2 Zn finger	387..407	CDD:275368	9/19 (47%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..463	CDD:275370	11/19 (58%)
		C2H2 Zn finger	488..508	CDD:275368	2/19 (11%)
		C2H2 Zn finger	516..536	CDD:275368	3/28 (11%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	14/19 (74%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		C2H2 Zn finger	656..676	CDD:275368	2/19 (11%)
		C2H2 Zn finger	684..704	CDD:275368	5/19 (26%)
		C2H2 Zn finger	712..732	CDD:275368	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12099
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010