DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and Zfp52

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	114/354 - (32%)
Similarity:	157/354 - (44%)	Gaps:	59/354 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 RPHKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHA 380
            |.|: |.|:..|.:.|..|.:.|...|.|..|.|:||..||:.|.:|.|.|...|:|..|.:||.
  Rat   457 RKHQ-KIHAGERRYGCKECSRSFTWFSNLRVHQRVHTGERPYRCKDCDKSFTTGSNLRVHQKIHT 520

  Fly   381 NEKPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFK 445
            .|||:.|..|..||...:.|..|.:||:||||:.|.||.|.|.:.:.|..|.:.|
  Rat   521 GEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECKKSFTRCSYLRDHQKIH---------- 575

  Fly   446 NGPHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEV 510
                                       ||     |......|.:....:.|..:  :.|||
  Rat   576 ---------------------------TG-----EKLYKCKDCNVSFMWISSLR--RHQKI---- 602

  Fly   511 LQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIH 575
              |.|.:|      .:|..|:|.|.|.:||..|..||...:||.|.:|...|...|.|.:|.:||
  Rat   603 --HTGEKP------YKCRECEKSFTQCSTLRDHQKIHTGEKPYKCKDCDISFLWISSLRRHQKIH 659

  Fly   576 TNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCP 640
            |.|||:.|..|...|...:.|..|.:||||||||||.:|.|.|.:.:.|..|.:||.|::|:.|
  Rat   660 TGEKPYKCKVCGISFLWISNLKTHQKIHTGEKPYKCQECNKSFTRCSYLRVHQKTHTGEKPYKC- 723

  Fly   641 MPNCRRRFATENEVTKHIDNHMNPNTTKV 669
             .:|...|...:.:.:|...|.....|.|
  Rat   724 -KDCGVSFMWISNLRRHQKIHTGEKHTVV 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		COG5048	355..666	CDD:227381	98/310 (32%)
		zf-C2H2	357..379	CDD:278523	7/21 (33%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		zf-C2H2	553..575	CDD:278523	7/21 (33%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	4/21 (19%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083
		C2H2 Zn finger	219..239	CDD:275368
		SFP1	<241..324	CDD:227516
		C2H2 Zn finger	247..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		COG5048	329..702	CDD:227381	100/301 (33%)
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..379	CDD:275368
		C2H2 Zn finger	388..407	CDD:275368
		C2H2 Zn finger	415..435	CDD:275368
		C2H2 Zn finger	443..463	CDD:275370	3/6 (50%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	5/27 (19%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	639..659	CDD:275368	6/19 (32%)
		C2H2 Zn finger	667..687	CDD:275368	5/19 (26%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
		zf-H2C2_2	707..730	CDD:404364	8/24 (33%)
		C2H2 Zn finger	723..743	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100