DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF680

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_848653.2	Gene:	ZNF680 / 340252	HGNCID:	26897	Length:	530	Species:	Homo sapiens

Alignment Length:	351	Identity:	119/351 - (33%)
Similarity:	156/351 - (44%)	Gaps:	87/351 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANE 382
            || |.::..::|||..|||.|...|.|.||.||||....:.|.||||.....|.|.:|..||..|
Human   172 HK-KRNTGKKVFKCKECGKSFCMLSHLTQHIRIHTRENSYKCEECGKVLNWFSELIKHKGIHMGE 235

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG 447
            ||:.|..|.::|.|.:.|.:|.:||..||||.|.||||.|...:||::|
Human   236 KPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKCEECGKAFSLFSILSKH---------------- 284

  Fly   448 PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQ 512
                                                                     ||:
Human   285 ---------------------------------------------------------KII----- 287

  Fly   513 HIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTN 577
            |.|.:|      .:|..|.|.|....||..|..||...:|:.|.||||.|.|.|:||:|.:|||.
Human   288 HTGDKP------YKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQFSNLTKHKKIHTG 346

  Fly   578 EKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMP 642
            |||:.|..|.:.|.|...|.:|.:||||||.|||.:|||.|.|.:.|.:|.|.|.|::|:.|  .
Human   347 EKPYKCEECGKAFNQFANLTRHKKIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTGEKPYKC--E 409

  Fly   643 NCRRRFATENEVTKHIDNHMNPNTTK 668
            .|.:.|...:.:|:|...|...||.|
Human   410 ECGKAFNGCSSLTRHKRIHTRENTYK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	98/310 (32%)
		zf-C2H2	357..379	CDD:278523	8/21 (38%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..396	CDD:290200	10/24 (42%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	11/21 (52%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF680	NP_848653.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	152..513	CDD:227381	119/351 (34%)
		zf-C2H2	182..204	CDD:278523	12/21 (57%)
		C2H2 Zn finger	184..204	CDD:275368	10/19 (53%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	224..249	CDD:290200	10/24 (42%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		zf-H2C2_2	253..276	CDD:290200	13/22 (59%)
		C2H2 Zn finger	268..288	CDD:275368	11/97 (11%)
		zf-H2C2_2	281..304	CDD:290200	10/106 (9%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..333	CDD:290200	11/23 (48%)
		C2H2 Zn finger	324..344	CDD:275368	11/19 (58%)
		zf-H2C2_2	336..361	CDD:290200	12/24 (50%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..389	CDD:290200	15/24 (63%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		zf-H2C2_2	392..416	CDD:290200	8/25 (32%)
		C2H2 Zn finger	408..428	CDD:275368	5/21 (24%)
		C2H2 Zn finger	436..456	CDD:275368	119/351 (34%)
		C2H2 Zn finger	464..484	CDD:275368
		zf-H2C2_2	477..501	CDD:290200
		zf-C2H2	490..512	CDD:278523
		C2H2 Zn finger	492..512	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100