DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF678

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_848644.2	Gene:	ZNF678 / 339500	HGNCID:	28652	Length:	580	Species:	Homo sapiens

Alignment Length:	341	Identity:	130/341 - (38%)
Similarity:	173/341 - (50%)	Gaps:	51/341 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANE 382
            || |.||..:.:.|..|||.|.|.|.|.||.||||..:|:.|.||.|.|.:.|:||||.|||..|
Human   254 HK-KIHSGEKPYPCEECGKAFTQFSNLTQHKRIHTGEKPYKCKECCKAFNKFSNLTQHKRIHTGE 317

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG 447
            ||:.|..|...|.:.:.|.:|.|||:||||:.|.||||.|.|.|.|.:|.|.|....|:...:.|
Human   318 KPYKCEECGNVFNECSHLTRHRRIHTGEKPYKCEECGKAFTQFASLTRHKRIHTGEKPYQCEECG 382

  Fly   448 ----------PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGK 502
                      .|..:...:.|:..|:                          .|..:..:....:
Human   383 KTFNRCSHLSSHKRIHTGEKPYKCEE--------------------------CGRTFTQFSNLTQ 421

  Fly   503 GQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSH 567
            .::|      |.|.:|      .:|..|.|.|.:.::|.||..||...:||.|.||||.|:|.||
Human   422 HKRI------HTGEKP------YKCKECGKAFNKFSSLTQHRRIHTGVKPYKCEECGKVFKQCSH 474

  Fly   568 LTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQ 632
            ||.|.||||.|||:.|..|.:.|.|.:||::|.||||.||||||.:|||.|.|.:.|.:|.|.|.
Human   475 LTSHKRIHTGEKPYKCKECGKAFYQSSILSKHKRIHTEEKPYKCEECGKAFNQFSSLTRHKRIHT 539

  Fly   633 GDRPFCCPMPNCRRRF 648
            |::.:.|  ..|.:.|
Human   540 GEKRYKC--KECGKGF 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	11/19 (58%)
		COG5048	355..666	CDD:227381	111/304 (37%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	13/24 (54%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	11/19 (58%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	14/21 (67%)
		C2H2 Zn finger	555..575	CDD:275368	13/19 (68%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	3/10 (30%)
ZNF678	NP_848644.2	KRAB	44..101	CDD:214630
		KRAB	44..83	CDD:279668
		COG5048	138..536	CDD:227381	124/320 (39%)
		C2H2 Zn finger	154..174	CDD:275368
		zf-H2C2_2	167..191	CDD:290200
		C2H2 Zn finger	182..202	CDD:275368
		zf-H2C2_2	194..218	CDD:290200
		C2H2 Zn finger	210..230	CDD:275368
		zf-H2C2_2	223..246	CDD:290200
		C2H2 Zn finger	238..258	CDD:275368	3/4 (75%)
		zf-H2C2_2	251..275	CDD:290200	10/21 (48%)
		C2H2 Zn finger	266..286	CDD:275368	11/19 (58%)
		zf-H2C2_2	278..302	CDD:290200	12/23 (52%)
		C2H2 Zn finger	294..314	CDD:275368	11/19 (58%)
		zf-H2C2_2	306..330	CDD:290200	12/23 (52%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-H2C2_2	334..359	CDD:290200	15/24 (63%)
		C2H2 Zn finger	350..370	CDD:275368	11/19 (58%)
		zf-H2C2_2	362..387	CDD:290200	6/24 (25%)
		C2H2 Zn finger	378..398	CDD:275368	2/19 (11%)
		zf-H2C2_2	390..415	CDD:290200	4/50 (8%)
		C2H2 Zn finger	406..426	CDD:275368	3/51 (6%)
		zf-H2C2_2	418..442	CDD:290200	7/35 (20%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		zf-H2C2_2	446..471	CDD:290200	13/24 (54%)
		C2H2 Zn finger	462..482	CDD:275368	13/19 (68%)
		zf-H2C2_2	474..497	CDD:290200	13/22 (59%)
		C2H2 Zn finger	490..510	CDD:275368	8/19 (42%)
		zf-H2C2_2	503..527	CDD:290200	16/23 (70%)
		C2H2 Zn finger	518..538	CDD:275368	9/19 (47%)
		zf-H2C2_2	530..553	CDD:290200	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010