DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and Gzf1

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001101258.1	Gene:	Gzf1 / 311508	RGDID:	1562321	Length:	707	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	167/718 - (23%)
Similarity:	266/718 - (37%)	Gaps:	184/718 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SEMYPNIQQQAQQHLTAQQQQQQQQQNAAQAAAQAAAVAAAAGQPQSPPGGGQEARDNGSGDGRQ 124
            ||....:::|..:.:..:.|...:.|..  .|:....|:.......|.| .|::|..||..|
  Rat   122 SETCLQLKKQMLESVLLELQNFSESQEV--EASSGPQVSVTPSSKASVP-AGEDAHSNGLVD--- 180

  Fly   125 QQVSPSSSPYPSVQQQQRANGAGDEDP---MNHQLANQQN----PAPNQNQSSNDPQHSGSNAGE 182
                  ||.||.   ::..||...|.|   ...:|..:::    |.|...::      ||..||:
  Rat   181 ------SSDYPI---ERLGNGLSPETPSKKCKEKLDKKKDVAKPPFPKIRRA------SGRLAGK 230

  Fly   183 SGNPHVQQNGGPQNDPGNSFRTPDYYDPRHAAPQGGMLAPPGFPPLHYLNKGVLPMEQSGGGGGA 247
            .....:         |...: |....:.:.:|.:..             .....|.:||...
  Rat   231 KVFVEI---------PKKKY-TRRLREQQKSAEEAA-------------KNDKCPQDQSPDN--- 269

  Fly   248 GGGEAYALPEMLPAQQNGQQNAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGN 312
                     |.:.|:...:..|.||:....|                      |:....|.:. .
  Rat   270 ---------ERVEAEPASKSEACPASVEREE----------------------SLQKVEGEKE-E 302

  Fly   313 GPGRPHKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARP---FPCSECGKRFRQQSHLTQ 374
            ..|:..:.|..|:   |:|..|.|.|..:.:.|:|.:.|.....   :.|..||:.|..:.:|..
  Rat   303 EEGKDGEEKKKSN---FQCTVCDKAFLYEKSFLKHIKYHHGVATEVVYRCDTCGQTFANRCNLKS 364

  Fly   375 HLR-IHANEKPFTCPYCSRSFRQRAILNQHI-RIH-SGEKPFACPECGKHFRQKAILNQHVRTHQ 436
            |.| :|::|:.|.|..|::.|:::..:.:|: ::| .|.:...|.:|||....|..|..|.|||
  Rat   365 HQRHVHSSERHFPCEMCAKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTH- 428

  Fly   437 DVSPHLIFKNGPHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDG 501
                             ..|.|:.....|.|                        ...||..|
  Rat   429 -----------------TGDKPYGCTKCDAK------------------------FSQPSALK-- 450

  Fly   502 KGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQS 566
                  ..:..|.|.||     :| |..|...|.|...|:.|...|...||:.|..|||.|..:.
  Rat   451 ------THLRVHTGERP-----FV-CDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKE 503

  Fly   567 HLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTH 631
            :|..|.||||..|||.|..|.|.|.||..|.||:::||||:||.|.||||.|.|...|.:|.|.|
  Rat   504 YLKHHNRIHTGSKPFKCEVCLRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQVNALQRHHRIH 568

  Fly   632 QGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNTT----KVRRQQQQQHQQQQQQQQQQQQQQQ 692
            .|::|:.|..  |.|.|..::.:.:|...| :.||.    .|......::.:.|:.:|..::.
  Rat   569 TGEKPYMCNA--CGRTFTDKSTLRRHTSIH-DKNTPWKSFLVIVDGSPKNDEGQKTEQPDEEY-- 628

  Fly   693 QQNNNAVAQVANHLMNDAKSLAAQQFLNN------NNPSAVDNKANILPVRSIASNAAAAAVVQQ 751
                 |..::::.|:    |.......||      |.|:..:|.         :::.|..|||.|
  Rat   629 -----ASPKLSDRLL----SFGENSHFNNLLEVQGNVPAVQENS---------STDTACKAVVSQ 675

  Fly   752 SVV 754
            ..:
  Rat   676 DAL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		COG5048	355..666	CDD:227381	95/316 (30%)
		zf-C2H2	357..379	CDD:278523	7/22 (32%)
		C2H2 Zn finger	359..379	CDD:275368	7/20 (35%)
		zf-H2C2_2	371..396	CDD:290200	9/25 (36%)
		C2H2 Zn finger	387..407	CDD:275368	4/20 (20%)
		zf-H2C2_2	400..424	CDD:290200	7/25 (28%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	8/21 (38%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		zf-H2C2_2	624..650	CDD:290200	10/25 (40%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
Gzf1	NP_001101258.1	BTB	21..125	CDD:279045	2/2 (100%)
		BTB	32..125	CDD:197585	2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..221		20/86 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..309		13/113 (12%)
		C2H2 Zn finger	318..338	CDD:275370	6/19 (32%)
		C2H2 Zn finger	349..370	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..428	CDD:275368	8/19 (42%)
		COG5048	<411..539	CDD:227381	53/183 (29%)
		C2H2 Zn finger	436..456	CDD:275368	5/51 (10%)
		zf-H2C2_2	448..473	CDD:290200	9/38 (24%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		zf-H2C2_2	476..501	CDD:290200	10/24 (42%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		zf-H2C2_2	504..529	CDD:290200	13/24 (54%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		zf-H2C2_2	532..557	CDD:290200	15/24 (63%)
		COG5048	544..>601	CDD:227381	22/59 (37%)
		C2H2 Zn finger	548..568	CDD:275368	10/19 (53%)
		zf-H2C2_2	560..584	CDD:290200	9/25 (36%)
		C2H2 Zn finger	576..596	CDD:275368	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100