DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF875

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_016882161.1	Gene:	ZNF875 / 284459	HGNCID:	4928	Length:	704	Species:	Homo sapiens

Alignment Length:	351	Identity:	117/351 - (33%)
Similarity:	176/351 - (50%)	Gaps:	52/351 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 KPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPF 385
            :.||.|:.:.|..||:.|..||.|:.|.|.||..:|:.|.|||:.|||.|||.:|.|.|:.|||:
Human   394 RTHSGLKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPY 458

  Fly   386 TCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG--- 447
            .|..|.:.|.|::.|.:|:|.|:||||:.|.|||:||..|:.|..|.|||..|.|::..:.|
Human   459 ICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCF 523

  Fly   448 -------PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQK 505
                   .|......:.||...:         .|.|:..:.:..|...:
Human   524 SLKSNLNKHQRSHTGEKPFVCTE---------CGRGFTRKSTLSTHQRT---------------- 563

  Fly   506 ILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQ 570
                   |.|.:|     :| |..|.:.|..|:||:.|...|...:|:.|.|||:||||:.:|.:
Human   564 -------HSGEKP-----FV-CAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFR 615

  Fly   571 HLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDR 635
            |.|.|:.  .|.|..|.:.|..:..|.:|.|.|.|.||:.|.:||:.|.:::.|.:|.|||.|::
Human   616 HKRAHSG--AFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRTHSGEK 678

  Fly   636 PFCCPMPNCRRRFATENEVTKHIDNH 661
            |:.|  ..|.|.|:.::.:.:|...|
Human   679 PYIC--RKCGRGFSRKSNLIRHQRTH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	103/317 (32%)
		zf-C2H2	357..379	CDD:278523	12/21 (57%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	11/21 (52%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	11/23 (48%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368
		COG5048	344..703	CDD:227381	117/351 (33%)
		C2H2 Zn finger	348..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368	0/1 (0%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	12/19 (63%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	10/19 (53%)
		C2H2 Zn finger	516..536	CDD:275368	2/19 (11%)
		C2H2 Zn finger	544..564	CDD:275368	3/51 (6%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	11/19 (58%)
		C2H2 Zn finger	626..646	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	7/19 (37%)
		C2H2 Zn finger	682..702	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000