DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZBTB11

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_055230.2	Gene:	ZBTB11 / 27107	HGNCID:	16740	Length:	1053	Species:	Homo sapiens

Alignment Length:	868	Identity:	188/868 - (21%)
Similarity:	289/868 - (33%)	Gaps:	276/868 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QQHLTAQQQQQQQ-----QQNAAQAAAQAAAVAAAAGQPQSPP-------------GGGQEARDN 117
            ::.||..::.:.|     |....|....|..||::.|...|.|             |...||..|
Human   313 EKQLTVYKKGEVQTVASTQDLRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQN 377

  Fly   118 GSGDGRQQQVSPSSSPYPSVQQQQRANGAG---DEDP----------------------MNHQLA 157
            |. .|||.:      |..|.:.:...:..|   |..|                      .|:.::
Human   378 GE-VGRQPE------PQVSSEAESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVS 435

  Fly   158 NQQNPAPNQNQSSNDPQHSGSN--------AGESGNPHVQQNGGPQNDPGNSFRT---------P 205
            |.......:|..|:.|:.||..        ..|....|.|:...|..|..|...:         .
Human   436 NIHPKLSKENVISSSPEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDD 500

  Fly   206 DYYDPR---HAAPQGGMLAPPGFPPLHYLNKGVLPMEQSGGGGGAGGGEAYALPEMLPAQ----- 262
            |.|..|   .:..:|..:.         |:||:....|          :..|:|:....|
Human   501 DTYRSRLRQRSVNEGAYIR---------LHKGMEKKLQ----------KRKAVPKSAVQQVAQKL 546

  Fly   263 -QNGQQNAGP---ANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNKPH 323
             |.|::...|   |..|..|                ||...|..|:....|...   ..||.| |
Human   547 VQRGKKMKQPKRDAKENTEE----------------ASHKCGECGMVFQRRYAL---IMHKLK-H 591

  Fly   324 SDLRLFKCLTCGKDFKQKST----LLQHDR----------------------------------- 349
            ...|.:||..|.|.|:..::    |::|.|
Human   592 ERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKGRTKREFICSIC 656

  Fly   350 ---------------IHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAI 399
                           .||..:|..|..|||.|..:..|..|..:|.::|.|.|..|.:||..:..
Human   657 GRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRS 721

  Fly   400 LNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVPFPGEDN 464
            |.:|:.||:||..:.|..|||.|.:.:.|::|.:.||           |.|.:
Human   722 LQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQ-----------PKPEV------------ 763

  Fly   465 DTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVRCPI 529
                      .|||....:           .|:|   :.:.:...:.:|:||:|      .:|..
Human   764 ----------RGYHCTQCE-----------KSFF---EARDLRQHMNKHLGVKP------FQCQF 798

  Fly   530 CDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFG---------CMY 585
            |||.:..|.....|...|..:.||.|..|||.|.:::...:|::..|:.|. |         |..
Human   799 CDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKK-GRAKQNLERVCEK 862

  Fly   586 CPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFAT 650
            |.|.|.|.....:|:..|.|.||::|..||..:.....|.:|.|||.|:||:.||:  |...:..
Human   863 CGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPV--CSEAYID 925

  Fly   651 ENEVTKHIDN-HMN--PNTTKVRRQQQQQHQQQQQ----------QQQQQQQQQQQQNNNAVAQV 702
            ...:.||:.. |.:  |....:.:...|.|.|..|          ..|:|:....|:....|  |
Human   926 ARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGMQEQESSGPQELETVV--V 988

  Fly   703 ANHLMNDAKSLAAQQFLNNNNPSAVDNKANILPVRSIASNAAAAAVVQQSVVKNELYFPQCYGPP 767
            ....|...:::||.:    ..||     .:.|..:||..........||....:|:
Human   989 TGETMEALEAVAATE----EYPS-----VSTLSDQSIMQVVNYVLAQQQGQKLSEV--------- 1035

  Fly   768 FQHPFQAQQQQAQQPSVAHANGG 790
                  |:..|..:..|||.:||
Human  1036 ------AEAIQTVKVEVAHISGG 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/73 (10%)
		COG5048	355..666	CDD:227381	87/322 (27%)
		zf-C2H2	357..379	CDD:278523	7/21 (33%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		zf-H2C2_2	371..396	CDD:290200	9/24 (38%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	7/21 (33%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	8/23 (35%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	639..661	CDD:275368	5/22 (23%)
ZBTB11	NP_055230.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..173
		BTB	204..305	CDD:279045
		BTB	215..306	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566		5/19 (26%)
		C2H2 Zn finger	571..591	CDD:275368	6/23 (26%)
		C2H2 Zn finger	599..619	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		2/23 (9%)
		C2H2 Zn finger	653..673	CDD:275368	0/19 (0%)
		zf-H2C2_2	665..690	CDD:290200	8/24 (33%)
		C2H2 Zn finger	681..701	CDD:275368	7/19 (37%)
		C2H2 Zn finger	709..729	CDD:275368	6/19 (32%)
		zf-H2C2_2	721..746	CDD:290200	11/24 (46%)
		C2H2 Zn finger	737..757	CDD:275368	7/19 (37%)
		C2H2 Zn finger	768..788	CDD:275368	2/33 (6%)
		zf-H2C2_2	780..804	CDD:290200	8/29 (28%)
		C2H2 Zn finger	796..816	CDD:275368	6/19 (32%)
		C2H2 Zn finger	860..880	CDD:275368	6/19 (32%)
		C2H2 Zn finger	888..908	CDD:275368	6/19 (32%)
		zf-H2C2_2	900..923	CDD:290200	11/24 (46%)
		C2H2 Zn finger	916..937	CDD:275368	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010