DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF718

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001034216.2	Gene:	ZNF718 / 255403	HGNCID:	26889	Length:	478	Species:	Homo sapiens

Alignment Length:	345	Identity:	122/345 - (35%)
Similarity:	166/345 - (48%)	Gaps:	50/345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 RLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCS 391
            :.|||..|||.|...|.|.||.||||...|:.|.||||.|...|.||:|.||||.||.:.|..|.
Human   169 KTFKCKECGKSFHVLSRLTQHKRIHTGENPYTCEECGKAFNWSSILTKHKRIHAREKFYKCEECG 233

  Fly   392 RSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG--------- 447
            :.|.:.:.|.:|.|||:||||:.|.:|||.|.|.:.||.|.|.|.....:...:.|
Human   234 KGFTRSSHLTKHKRIHTGEKPYICEKCGKAFNQSSTLNLHKRIHSAQKYYKCEECGKAFKWSSSL 298

  Fly   448 -PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVL 511
             .|..:...:.||..|:   .|::..|...:                       .|.::|
Human   299 NEHKRIHAGEKPFSCEE---CGNVFTTSSDF-----------------------AKHKRI----- 332

  Fly   512 QHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHT 576
             |.|.:|      .:|..|.|.|.:.|||..|..||...:||.|.||||.|...|.|..|.|||:
Human   333 -HTGEKP------YKCEECGKSFNRSTTLTTHKRIHTGEKPYTCEECGKAFNWSSTLNVHKRIHS 390

  Fly   577 NEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPM 641
            .:.|:.|..|.:.|:....|:.|.:||||||||.|.||||.|:|.:.|::|.:.|..|:|:.|
Human   391 GKNPYKCEDCGKAFKVFANLHNHKKIHTGEKPYICKQCGKAFKQSSHLNKHKKIHTVDKPYKC-- 453

  Fly   642 PNCRRRFATENEVTKHIDNH 661
            ..|.:.|...:.:.:|...|
Human   454 KECGKAFKQYSNLPQHKRTH 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	107/317 (34%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		zf-C2H2	553..575	CDD:278523	11/21 (52%)
		C2H2 Zn finger	555..575	CDD:275368	10/19 (53%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	4/21 (19%)
ZNF718	NP_001034216.2	KRAB	4..64	CDD:214630
		C2H2 Zn finger	146..165	CDD:275368
		C2H2 Zn finger	173..193	CDD:275368	10/19 (53%)
		C2H2 Zn finger	201..221	CDD:275368	11/19 (58%)
		COG5048	<225..386	CDD:227381	56/198 (28%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	10/19 (53%)
		C2H2 Zn finger	285..305	CDD:275368	2/19 (11%)
		C2H2 Zn finger	313..333	CDD:275368	5/51 (10%)
		COG5048	<322..474	CDD:227381	61/189 (32%)
		C2H2 Zn finger	341..361	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	10/19 (53%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		C2H2 Zn finger	453..473	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100