DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and znf-782

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	163/736 - (22%)
Similarity:	229/736 - (31%)	Gaps:	274/736 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 EMLPAQQNGQQNAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNK 321
            |.|...:|....:...:..:..|.:.:|||.  |.:....|...|.|   .|.:|:..|:|.|.
Worm    45 EELEELENSDSASSLVSAGSPHGSSSSNGSH--GSSPPLQVQSPSQG---SGSSGSPTGQPEKR- 103

  Fly   322 PHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFT 386
             |.      |..|||.|...|.|..|.|.||..:|:.|..|.|.|.|::.|..|.|.|..|:|:.
Worm   104 -HI------CTVCGKGFSYFSILESHKRSHTGEKPYNCHFCQKTFAQKATLQVHERTHTGERPYK 161

  Fly   387 CPYCSRSFRQRAILNQHIR-IHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHP 450
            |.||.::|.|......|.: .|.|.:.:.||:|.|.....:.|..|.:||.|.:
Worm   162 CRYCEKTFAQYGTKTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTHGDKT----------- 215

  Fly   451 TLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIG 515

Worm   216 ----------------------------------------------------------------- 215

  Fly   516 VRPANMPLYVRCPICDKEFKQKTTLLQH-GCIHIES-RPYPCPECGKRFRQQSHLTQHLRIHTNE 578
                     .||..|.|.|..|..|..| ..:|.:: |.:.|..|.|.|.....|..|:|.||.|
Worm   216 ---------FRCDFCPKTFALKNYLKLHVKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGE 271

  Fly   579 KPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPN 643
            :|:.|.:||:.|..:..|..|.|.||||:||.|..|.:.|.||:.|..|..||...:....|...
Worm   272 RPYVCKFCPKAFASQGNLQSHERTHTGERPYSCQFCQRTFIQKSQLTAHESTHLTQKHSVNPDST 336

  Fly   644 CRRRFATENEVTKH--IDN------------------HMNPNTTK-------VRRQQQQQ----- 676
            ..........||.|  :.|                  ||..:|.|       ..:...|:
Worm   337 TADILPVAGSVTDHQMVGNYECTFCNKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQKISLNI 401

  Fly   677 HQQQQQQQQQQQQQQQQQ--------NNNAVAQVANHLMNDA----KSLA-----AQQFLNNNNP 724
            ||.|.:..:.:.:....|        ..:.|.::|..:..|:    |:||     .||..|.|:.
Worm   402 HQDQCEAFKNRLKTTDSQFSHNCDGCGKSFVQRIALQIHVDSCEPHKNLARLKLSQQQNQNQNSD 466

  Fly   725 SAVDNKANILPVRSIASNAAAAAVVQQSVVKNELYFPQCYGPPFQHPFQAQQQQAQQPSVAHANG 789
            |..|.:..|.|:
Worm   467 SESDTEMKICPL----------------------------------------------------- 478

  Fly   790 GPTPPVTVTVANSVASGVVVQQNASASVVAQXHPTTAATGAQQQQPSAPQQQHHPPP-------P 847
             |.||:|:                                       ||..|..|||       |
Worm   479 -PNPPLTL---------------------------------------APTHQQIPPPVNIYAQQP 503

  Fly   848 PPTSTAHHIASAAAAVTAVTPSSAHASPVAAPQTVTLSITLPP-PPASHTVHPGHPGHPGHP-GV 910
            ||......:.:     |::||.             ||:..||. ..||.:....|.  |..| .:
Worm   504 PPNPLGSILGN-----TSLTPQ-------------TLNFGLPSLSSASFSSLNAHA--PFTPVEL 548

  Fly   911 ANGAAPPPPTLS--HAIPIHP 929
            .|.|...|.|.|  ||:|.||
Worm   549 PNSADFGPLTASKPHAVPFHP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	79/333 (24%)
		zf-C2H2	357..379	CDD:278523	8/21 (38%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..396	CDD:290200	10/24 (42%)
		C2H2 Zn finger	387..407	CDD:275368	6/20 (30%)
		zf-H2C2_2	400..424	CDD:290200	7/24 (29%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/20 (35%)
		zf-C2H2	553..575	CDD:278523	7/21 (33%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	596..620	CDD:290200	12/23 (52%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	5/25 (20%)
		C2H2 Zn finger	639..661	CDD:275368	5/41 (12%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	9/19 (47%)
		zf-H2C2_2	119..143	CDD:290200	10/23 (43%)
		C2H2 Zn finger	134..154	CDD:275368	8/19 (42%)
		zf-H2C2_2	147..171	CDD:290200	10/23 (43%)
		C2H2 Zn finger	162..180	CDD:275368	6/17 (35%)
		COG5048	<187..404	CDD:227381	63/301 (21%)
		C2H2 Zn finger	191..211	CDD:275370	6/19 (32%)
		C2H2 Zn finger	218..239	CDD:275368	7/20 (35%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..285	CDD:290200	11/24 (46%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	12/24 (50%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..403	CDD:275368	1/16 (6%)
		C2H2 Zn finger	424..441	CDD:275368	2/16 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910