DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF100

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_775802.2	Gene:	ZNF100 / 163227	HGNCID:	12880	Length:	542	Species:	Homo sapiens

Alignment Length:	351	Identity:	119/351 - (33%)
Similarity:	164/351 - (46%)	Gaps:	59/351 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANE 382
            || :.|.....::|..|||.|...|||..|.||||..:|:.|.||||.|.:.||||.|..||..|
Human   223 HK-RFHITENSYQCKDCGKAFNWFSTLTTHRRIHTGEKPYKCEECGKAFNRSSHLTTHKIIHTGE 286

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG 447
            ||:.|..|.::|.:.:.|..|.|||:|.||:.|.||||.|.:    :.|:.||:      |...|
Human   287 KPYRCEECGKAFNRSSHLTTHKRIHTGVKPYKCTECGKAFNR----SSHLTTHR------IIHTG 341

  Fly   448 PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQ 512
                    :.|:..|:         .|..::...:..|                       ..:.
Human   342 --------EKPYKCEE---------CGKAFNQSSTLTT-----------------------HKIT 366

  Fly   513 HIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTN 577
            |.|.:|      .:|..|.|.|.:.:.|.:|...|...:.|.|.||||.|...|.||:|.||||.
Human   367 HAGEKP------YKCEECGKAFYRFSYLTKHKTSHTGEKFYKCEECGKGFNWSSALTKHKRIHTG 425

  Fly   578 EKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMP 642
            |||:.|..|.:.|.:.:.|..|..||||||||||.:|||.|.:.:.|..|...|.|::|:.|  .
Human   426 EKPYKCEECGKAFNESSNLTTHKMIHTGEKPYKCDECGKAFNRSSQLTAHKMIHTGEKPYKC--E 488

  Fly   643 NCRRRFATENEVTKHIDNHMNPNTTK 668
            .|.:.|...:.:|||...|....:.|
Human   489 ECGKAFNRSSTLTKHKITHTGEKSYK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	102/310 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	6/21 (29%)
ZNF100	NP_775802.2	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	150..534	CDD:227381	119/351 (34%)
		C2H2 Zn finger	207..227	CDD:275368	2/4 (50%)
		C2H2 Zn finger	235..255	CDD:275368	10/19 (53%)
		zf-H2C2_2	248..272	CDD:290200	13/23 (57%)
		C2H2 Zn finger	263..283	CDD:275368	11/19 (58%)
		zf-H2C2_2	275..300	CDD:290200	12/24 (50%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		zf-H2C2_2	303..328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	319..339	CDD:275368	10/29 (34%)
		zf-H2C2_2	331..356	CDD:290200	8/47 (17%)
		C2H2 Zn finger	347..367	CDD:275368	3/51 (6%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	11/19 (58%)
		zf-H2C2_2	415..439	CDD:290200	12/23 (52%)
		C2H2 Zn finger	431..451	CDD:275368	5/19 (26%)
		zf-H2C2_2	443..468	CDD:290200	16/24 (67%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		zf-H2C2_2	472..496	CDD:290200	8/25 (32%)
		C2H2 Zn finger	487..507	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100