DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF519

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_660330.2	Gene:	ZNF519 / 162655	HGNCID:	30574	Length:	540	Species:	Homo sapiens

Alignment Length:	596	Identity:	157/596 - (26%)
Similarity:	216/596 - (36%)	Gaps:	206/596 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 GSGDGRQQQVSPSSSPYPSVQQQQRANGAGDED--------------------PMN---HQLANQ 159
            |.|:| |::.....|.|.:....:.....||::                    |||   |:....
Human    89 GEGEG-QKECYNLCSQYLTTSHNKHLTVKGDKEYRIFQKKPQFLSAAPTEPCIPMNKYQHKFLKS 152

  Fly   160 QNPAPNQ---NQSSNDPQHSGSNAGES--------------------GNPHVQQNGGPQNDPGNS 201
            .....||   |..||..:|..::..|:                    .|.|:|:.      |.||
Human   153 VFCNKNQINFNHDSNISKHHSTHFLENYYNCNECEKVFYQSSKLIFPENIHIQKK------PYNS 211

  Fly   202 FRTPDYYDPRHAAPQGGMLAPPGFPPLHYL--------NKGVLPMEQSGGGGGAGGGEAYALPEM 258
            ....:..||.....|...:         |:        .|.::...||
Human   212 NECGETSDPFSKLTQHQRI---------YIGESSQRCNKKCIIVFSQS----------------- 250

  Fly   259 LPAQQNGQQ--NAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKNK 321
               ...|.:  |.|..:....|.|.                     ..|.|...|:       .|
Human   251 ---HLKGHKIINTGEKSVKYKERGK---------------------AFTRGLHLGH-------QK 284

  Fly   322 PHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFT 386
            .|:..:.:||..|.|.|.:.|.|.||.||||..:||.|.||||.|.:.|:||||.|||..|:.|.
Human   285 IHTGEKPYKCKKCDKAFNKSSHLAQHQRIHTGEKPFKCKECGKAFNRGSYLTQHQRIHTGERAFK 349

  Fly   387 CPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPT 451
            |..|.::|.:.:.|.||.|||:|||||.|.||||.|.:.:.:.||.|
Human   350 CEECGKAFNRGSYLTQHQRIHTGEKPFRCKECGKAFNRSSYVTQHQR------------------ 396

  Fly   452 LWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGV 516
                                                                        .|.|.
Human   397 ------------------------------------------------------------MHTGE 401

  Fly   517 RPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPF 581
            :|      .:|..|.|.|.:.:.|.||..||...:.:.|.||||.|.:.||||:|.||||.||.|
Human   402 KP------FKCKECGKAFNRASHLTQHQRIHTGEKHFKCKECGKAFNRGSHLTRHQRIHTGEKSF 460

  Fly   582 GCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRR 646
            .|..|.:.|...:.|.||.|:|||||.:||.:|||.|.:.:.|.||.|.|.|::||.|  ..|.:
Human   461 KCEECGKAFIWGSHLTQHQRVHTGEKFFKCKECGKAFTRSSHLTQHQRIHTGEKPFKC--KECGK 523

  Fly   647 RFATENEVTKH 657
            .|...:.:|:|
Human   524 AFNRRSTLTQH 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	102/303 (34%)
		zf-C2H2	357..379	CDD:278523	13/21 (62%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	17/23 (74%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	12/19 (63%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
ZNF519	NP_660330.2	KRAB	4..43	CDD:279668
		KRAB	4..>43	CDD:214630
		C2H2 Zn finger	183..229	CDD:275368	9/51 (18%)
		zf-H2C2_2	282..302	CDD:290200	6/26 (23%)
		COG5048	290..>539	CDD:227381	115/331 (35%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	15/24 (63%)
		C2H2 Zn finger	322..342	CDD:275368	12/19 (63%)
		zf-H2C2_2	334..359	CDD:290200	12/24 (50%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..387	CDD:290200	17/24 (71%)
		C2H2 Zn finger	378..398	CDD:275368	9/97 (9%)
		zf-H2C2_2	393..415	CDD:290200	10/105 (10%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..443	CDD:290200	11/24 (46%)
		C2H2 Zn finger	434..454	CDD:275368	12/19 (63%)
		zf-H2C2_2	446..469	CDD:290200	13/22 (59%)
		C2H2 Zn finger	462..482	CDD:275368	7/19 (37%)
		zf-H2C2_2	474..499	CDD:290200	15/24 (63%)
		C2H2 Zn finger	490..510	CDD:275368	9/19 (47%)
		zf-H2C2_2	502..527	CDD:290200	11/26 (42%)
		C2H2 Zn finger	518..538	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010