DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF714

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_872321.2	Gene:	ZNF714 / 148206	HGNCID:	27124	Length:	555	Species:	Homo sapiens

Alignment Length:	405	Identity:	134/405 - (33%)
Similarity:	183/405 - (45%)	Gaps:	68/405 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKP-HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHAN 381
            |::|. |.....::|..|.|.||:.|||.:|.|:||..:||.|.||||.|:..|.||.|..||..
Human   161 HQHKRIHIRENSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKCEECGKAFKHSSTLTTHKMIHTG 225

  Fly   382 EKPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKN 446
            |||:.|..|.::|...:.|..|..||:|||||.|.||||.|...:.|..|...|
Human   226 EKPYRCEECGKAFYHSSHLTTHKVIHTGEKPFKCEECGKAFNHPSALTTHKFIH----------- 279

  Fly   447 GPHPTLWPSDVPFPGEDND---------TKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGK 502
                   ..:.|:..|:.|         ||..|..:|     |.|........|.::.|.....|
Human   280 -------VKEKPYKCEECDKAFNRFSYLTKHKIIHSG-----EKSYKCEQCGKGFNWSSTLTKHK 332

  Fly   503 ----GQK----------------ILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIH 547
                |:|                :....:.|.|.:|      .:|..|.|.|...:.|..|..||
Human   333 RIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKP------YKCEECGKAFNHSSKLTIHKIIH 391

  Fly   548 IESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCG 612
            ...:||.|.||||.|.|.|:||:|..|||.||.:.|..|.:.|.:.:.|..|.|||||||||||.
Human   392 TGEKPYKCEECGKAFNQSSNLTKHKIIHTGEKLYKCEECGKAFNRSSNLTTHKRIHTGEKPYKCE 456

  Fly   613 QCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKH-------IDNHMNPNTTKVR 670
            :|||.|.:.:.|.:|...|.|::.:.|  ..|.:.|...:.:|||       :.:..||||.:..
Human   457 ECGKAFNRSSNLTKHNIIHTGEKSYKC--EECGKAFNQSSTLTKHRKIQQGMVAHACNPNTLRGL 519

  Fly   671 RQQQQQHQQQQQQQQ 685
            .:|..:...|.|..|
Human   520 GEQIARSGVQDQPGQ 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	113/346 (33%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	11/24 (46%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	12/21 (57%)
		C2H2 Zn finger	555..575	CDD:275368	11/19 (58%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	17/23 (74%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	7/25 (28%)
		C2H2 Zn finger	639..661	CDD:275368	6/28 (21%)
ZNF714	NP_872321.2	KRAB	<2..36	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	2/5 (40%)
		COG5048	171..504	CDD:227381	123/363 (34%)
		C2H2 Zn finger	175..195	CDD:275368	10/19 (53%)
		zf-H2C2_2	188..212	CDD:290200	13/23 (57%)
		C2H2 Zn finger	203..223	CDD:275368	10/19 (53%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		zf-H2C2_2	243..268	CDD:290200	15/24 (63%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	3/19 (16%)
		zf-H2C2_2	328..351	CDD:290200	3/22 (14%)
		C2H2 Zn finger	343..363	CDD:275368	0/19 (0%)
		zf-H2C2_2	355..380	CDD:290200	7/30 (23%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..408	CDD:290200	12/23 (52%)
		C2H2 Zn finger	399..419	CDD:275368	11/19 (58%)
		zf-H2C2_2	411..436	CDD:290200	11/24 (46%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..464	CDD:290200	17/24 (71%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..492	CDD:290200	7/26 (27%)
		C2H2 Zn finger	483..502	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010