DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and ZNF460

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_006626.3	Gene:	ZNF460 / 10794	HGNCID:	21628	Length:	562	Species:	Homo sapiens

Alignment Length:	415	Identity:	122/415 - (29%)
Similarity:	184/415 - (44%)	Gaps:	71/415 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 FKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRS 393
            :.|..|||.|.:...||||..|||..:|:.|.||||.|.::||||:|.|.|..:|||.|..|.|:
Human   196 YDCPECGKAFGKSKHLLQHHIIHTGEKPYKCLECGKDFNRRSHLTRHQRTHNGDKPFVCSECGRT 260

  Fly   394 FRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVP 458
            |.:.:.|.:|.|:|||||||.|.||||.|..::....|.::|.:..|..
Human   261 FNRGSHLTRHQRVHSGEKPFVCNECGKAFTYRSNFVLHNKSHNEKKPFA---------------- 309

  Fly   459 FPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPL 523
                       .:..|.|:::..:                       ::...:.|.|.||
Human   310 -----------CSECGKGFYESTA-----------------------LIQHFIIHTGERP----- 335

  Fly   524 YVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPR 588
             .:|..|.|.|..::.|.||..||...:|:.|.:|||.|...|....|.|.||.||||.|..|.:
Human   336 -FKCLECGKAFNCRSHLKQHERIHTGEKPFVCSQCGKAFTHYSTYVLHERAHTGEKPFECKECGK 399

  Fly   589 FFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENE 653
            .|..|..|.:|..||||||||:|.||||.|.:.:.|.:|...|.|::|:.|  ..|.:.|.....
Human   400 AFSIRKDLIRHFNIHTGEKPYECLQCGKAFTRMSGLTRHQWIHTGEKPYVC--IQCGKAFCRTTN 462

  Fly   654 VTKHIDNHMNPNTTKV--------RRQQQQQHQQQQQQQQQQQQQQQQQNNNAVAQVANH--LMN 708
            :.:|...|......:.        ||....:||:....::..:..|....:.....:..|  :..
Human   463 LIRHFSIHTGEKPYECVECGKAFNRRSPLTRHQRIHTAEKSHEPIQSGNVSCESTDLIQHSIIHT 527

  Fly   709 DAKSLAAQQFLNNNNPSAVDNKANI 733
            ::..::|   :|...||...:.:::
Human   528 ESSPVSA---VNMETPSIAAHSSSL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	100/310 (32%)
		zf-C2H2	357..379	CDD:278523	12/21 (57%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	13/24 (54%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	400..424	CDD:290200	16/23 (70%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		zf-C2H2	553..575	CDD:278523	8/21 (38%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	16/23 (70%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	4/21 (19%)
ZNF460	NP_006626.3	KRAB	12..53	CDD:307490
		C2H2 Zn finger	198..218	CDD:275368	9/19 (47%)
		COG5048	222..552	CDD:227381	110/389 (28%)
		C2H2 Zn finger	226..246	CDD:275368	12/19 (63%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..330	CDD:275368	2/42 (5%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		C2H2 Zn finger	450..470	CDD:275368	4/21 (19%)
		C2H2 Zn finger	478..498	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010